Antioxidant therapy to prevent preeclampsia: a randomized controlled trial.

  title={Antioxidant therapy to prevent preeclampsia: a randomized controlled trial.},
  author={Joseph A. Spinnato and S{\'a}lvio Freire and Jo{\~a}o Luiz de Carvalho Pinto e Silva and Marilza Vieira Cunha Rudge and S{\'e}rgio Martins-Costa and Matthew A. Koch and Norman Goco and Cleide de Barros Santos and Jos{\'e} Guilherme Cecatti and Roberto Costa and Jos{\'e} Geraldo Lopes Ramos and Nancy Moss and Baha M. Sibai},
  journal={Obstetrics and gynecology},
  volume={110 6},
OBJECTIVE To study whether antioxidant supplementation will reduce the incidence of preeclampsia among patients at increased risk. METHODS A randomized, placebo-controlled, double-blind clinical trial was conducted at four Brazilian sites. Women between 12 0/7 weeks and 19 6/7 weeks of gestation and diagnosed to have chronic hypertension or a prior history of preeclampsia were randomly assigned to daily treatment with both vitamin C (1,000 mg) and vitamin E (400 International Units) or… CONTINUE READING


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