Antioxidant therapy in intensive care

@article{Lovat2003AntioxidantTI,
  title={Antioxidant therapy in intensive care},
  author={Robin Lovat and Jean-Charles Preiser},
  journal={Current Opinion in Critical Care},
  year={2003},
  volume={9},
  pages={266-270}
}
Purpose of reviewThis review intends to summarize the recent findings regarding the presence of increased oxidative stress in critically ill patients and its potential pathophysiologic role, as well as the results of recent clinical trials of antioxidant therapies. Recent findingsSeveral lines of evidence confirm the increase in oxidative stress during critical illness. The oxidative damage to cells and tissues eventually contributes to organ failure. Prophylactic administration of antioxidant… 
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TLDR
The background rationale and study protocol for the evaluation of the effect of high-dose glutamine and antioxidant supplementation on mortality in a large-scale randomized trial in 1200 mechanically-ventilated, critically-ill patients are reported.
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Selenium, by supporting antioxidant function, may be associated with a reduction in mortality, and large, well-designed randomized trials are required to demonstrate this.
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The hypothesis that improving selenium status and hence reinforcing the endogenous AOX defenses are beneficial in defined conditions is supported, but there are shortcomings and some concerns to this study.
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Purpose of reviewThis review is dedicated to updating the knowledge on oxidative stress in critically ill patients with an intense inflammatory reaction, and to link it with recent findings…
Antioxidant micronutrients in the critically ill: a systematic review and meta-analysis
TLDR
Supplementation with high dose trace elements and vitamins may improve outcomes of critically ill patients, particularly those at high risk of death.
Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: a cohort study
TLDR
The critical condition of patients admitted to the ICU is associated with worsening oxidative stress and intake of antioxidant vitamins should be carefully monitored so that it is as close as possible to RDA.
Impact of high-dose antioxidants on outcomes in acutely injured patients.
TLDR
A high-dose antioxidant protocol for acutely injured patients admitted to the trauma service between October 2005 and September 2006 resulted in a 28% relative risk reduction in mortality and a significant reduction in both hospital and ICU length of stay.
Research Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: a cohort
TLDR
The critical condition of patients admitted to the ICU is associated with worsening oxidative stress and intake of antioxidant vitamins should be carefully monitored so that it is as close as possible to RDA.
Pharmaconutrition with antioxidant micronutrients in the critically ill: the time has come!
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