Antioxidant therapy in critical care—Is the microcirculation the primary target?

@article{Biesalski2007AntioxidantTI,
  title={Antioxidant therapy in critical care—Is the microcirculation the primary target?},
  author={H. Biesalski and G. Mcgregor},
  journal={Critical Care Medicine},
  year={2007},
  volume={35},
  pages={S577-S583}
}
This review presents the rationale for the therapeutic use of antioxidants in treating critically ill patients; it is not a systematic review of the clinical evidence that has been assessed recently by others. Clinical and nonclinical evidence is presented to support the notion that natural antioxidants are of therapeutic value in treating cardiovascular shock. Oxidative stress is a major promoter and mediator of the systemic inflammatory response. The microcirculation is particularly… Expand
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References

SHOWING 1-10 OF 68 REFERENCES
Oxidative stress and role of antioxidant supplementation in critical illness.
The role of oxidative stress in adult critical care.
Rationale and impact of vitamin C in clinical nutrition
Randomized, Prospective Trial of Antioxidant Supplementation in Critically Ill Surgical Patients
Inflammation-induced vasoconstrictor hyporeactivity is caused by oxidative stress.
Antioxidant micronutrients in major trauma and burns: evidence and practice.
  • M. Berger
  • Medicine
  • Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
  • 2006
Antioxidants in critical illness.
Oxidative stress in critically ill patients.
  • Caryl Goodyear-Bruch, J. Pierce
  • Medicine
  • American journal of critical care : an official publication, American Association of Critical-Care Nurses
  • 2002
...
1
2
3
4
5
...