Antioxidant strategies based on tomato-enriched food or pyruvate do not affect disease onset and survival in an animal model of amyotrophic lateral sclerosis.

@article{Esposito2007AntioxidantSB,
  title={Antioxidant strategies based on tomato-enriched food or pyruvate do not affect disease onset and survival in an animal model of amyotrophic lateral sclerosis.},
  author={Ennio Esposito and Margherita Capasso and Nora di Tomasso and Carlo Corona and Fabio Pellegrini and A Uncini and Paola Vitaglione and Vincenzo Fogliano and Mauro Piantelli and Stefano L Sensi},
  journal={Brain research},
  year={2007},
  volume={1168},
  pages={90-6}
}
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder which is mostly sporadic, although about 5-10% of the cases are inherited. About 15-20% of patients with familial ALS (FALS) carry mutations in the gene encoding the free radical scavenging enzyme Cu/Zn superoxide dismutase (SOD1). In this study, we explored the potential neuroprotective effects of antioxidant strategies based on either a tomato-enriched diet, or pyruvate administration, in an animal model of ALS. To that… CONTINUE READING
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