Antioxidant status in patients with uncomplicated insulin‐dependent and non‐insulin‐dependent diabetes mellitus

  title={Antioxidant status in patients with uncomplicated insulin‐dependent and non‐insulin‐dependent diabetes mellitus},
  author={S. R. J. Maxwell and Helen Thomason and D Sandler and Ca Leguen and M. A. Baxter and Ghg Thorpe and A. F. Jones and Anthony H. Barnett},
  journal={European Journal of Clinical Investigation},
Oxidative damage by free radicals has been implicated in the pathogenesis of vascular disease in diabetes. We compared the radical‐scavenging antioxidant activity of serum from 28 patients with insulin‐dependent diabetes mellitus and 24 patients with non‐insulin‐dependent diabetes mellitus uncomplicated by vascular disease with age‐matched non‐diabetic control subjects. Patients with insulin‐dependent diabetes had significantly reduced total antioxidant activity (320.2 ± 11.3 vs. 427.5 ± 19.2… 
Poor Glycaemic Control is Associated with Reduced Serum Free Radical Scavenging (Antioxidant) Activity in Non-Insulin-Dependent Diabetes Mellitus
Results indicate that poor diabetic control is associated with reduced serum free radical scavenging (antioxidant) activity in non-insulin-dependent diabetes mellitus, and by implication improved glycaemic control may preserve serum antioxidant status in diabetes.
Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus
Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity, and oxidative stress levels were not different between diabetic and nondiabetic patients.
Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients
The data suggest that microalbuminuria in type 2 diabetic patients might be promoted by an insufficient counter-regulation of the antioxidant system in the event of increased glyco-oxidation/glycation.
Increased pro-Oxidant- Antioxidant Balance in Patients with Diabetes Mellitus
The findings indicate that this assay could be used along with other risk factors to estimate the oxidative stress in high-risk patients, and there is an imbalance between serum pro-oxidant and antioxidant activity in diabetics.
b-Carotene affects antioxidant status in non-insulin-dependent diabetes mellitus
Natural b-carotene affects the glutathione and part of its redox cycle enzymes by potential augmentation of its regeneration, and restoring antioxidant status may slow the rate of development of vascular complications in diabetes mellitus.
The role of oxidative stress in diabetic retinopathy
Free radicals forming in diabetes mellitus and increasing over time may play a role in the development of diabetic retinopathy, which is an important complication of the disease.
Association Of Poor Glycemic Control With Increased Lipid Peroxidation And Reduced Antioxidant Vitamin Status In Diabetic Neuropathy
Findings indicate in diabetic neuropathy oxidative stress is inversely related to the glycemic control, which could be the unifying mechanism that leads to nervous system damage causing diabetic Neuropathy.
Depletion of total antioxidant capacity in type 2 diabetes.
Effect of vitamin C supplementation on postprandial oxidative stress and lipid profile in type 2 diabetic patients.
It is suggested that vitamin C supplementation can decrease fasting and postprandial oxidative stress and may prevent diabetes complication.


Free Radical Activity in Type 2 Diabetes
A reduction in superoxide dismutase and the imbalance in the redox status of the plasma and lysate thiol demonstrated is consistent with an increase in free radical activity in Type 2 diabetes.
Antioxidant status and lipid peroxidation in type II diabetes mellitus with and without complications.
The results suggest that the antioxidant deficiency and excessive peroxide-mediated damage may appear early on in non-insulin-dependent diabetes mellitus, before the development of secondary complications.
Vitamin C metabolites and microangiopathy in diabetes mellitus.
The results suggest that diabetics may be less able to prevent oxidative damage occurring due to their lower AA concentrations, and the plasma ratio DHAA/AA may be a reflection of increased oxidative stress.
Vitamins and trace metals status in non insulin dependent diabetes mellitus.
  • E. Havivi, H. Bar On, A. Reshef, P. Stein, I. Raz
  • Medicine
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 1991
It is concluded that vitamin and metal deficiency is common in Non Insulin Dependent Diabetes Mellitus subjects and percent of diabetic patients with various vitamin or metal deficiencies were significantly higher than those in the healthy population.
Ascorbic acid metabolism in diabetes mellitus.
The Fluorescence of Serum Proteins in Diabetic Patients with and without Retinopathy
The fluorescence of serum albumin and IgG were not significantly correlated with serum protein glycosylation measured by the fructosamine method and there was no significant difference in the fluorescence ratios of albumin in those with and without retinopathy.
Urine uric acid excretion in patients with insulin-dependent diabetes mellitus.
No correlation was found between the fractional excretion of uric acid and the degree of glycosuria in IDDM patients, and the prevalence of hypouricemia was the same in patients and controls.
Plasma vitamin A and E in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) adult diabetic patients.
Vitamin A and E status was studied in 35 type 1 and 35 type 2 diabetic patients and in 30 control subjects and no correlation was found between vitamin A blood concentration and blood glucose control as evaluated with HbA1c.
New Insights on Non‐enzymatic Glycosylation May Lead to Therapeutic Approaches for the Prevention of Diabetic Complications
These findings suggest the possibility that oxidative stress may be related to the development of diabetic complications and may lead to new therapeutic approaches for the prevention of complications by limiting the damage caused by non‐enzymatic glycosylation and oxidant stress.
Reduced Plasma Peroxyl Radical Trapping Capacity and Increased Susceptibility of LDL to Oxidation In Poorly Controlled IDDM
The reduced TRAP of plasma and the increased susceptibility of LDL to oxidative modification observed is consistent with a role for lipoprotein oxidation in the pathogenesis of atherosclerosis in IDDM.