Antioxidant status in patients with acute respiratory distress syndrome

@article{Metnitz1999AntioxidantSI,
  title={Antioxidant status in patients with acute respiratory distress syndrome},
  author={Ph. G. H. Metnitz and Christian Bartens and M. Fischer and Peter Fridrich and Heinz Steltzer and Wilfred Druml},
  journal={Intensive Care Medicine},
  year={1999},
  volume={25},
  pages={180-185}
}
Objectives: Reactive oxygen species (ROS) have been implicated in the pathophysiology of ARDS. We investigated the pattern of antioxidants in plasma and ROS production by neutrophils in patients with ARDS over 6 days. Design: Observational study. Blood samples were taken when the diagnosis was made (D0) and after 3 (D3) and 6 days (D6) during therapy. Setting: Intensive care units at a University Hospital. Patients: Eight patients with ARDS were investigated, 17 healthy volunteers served as… 
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References

SHOWING 1-10 OF 23 REFERENCES
Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome.
TLDR
It is concluded that ARDS is associated with oxidative stress, possibly exerted by oxidants released from activated phagocytic leukocytes, and major changes in plasma cholesterol metabolism.
Serum antioxidants as predictors of adult respiratory distress syndrome in patients with sepsis
Antioxidant status in patients on chronic hemodialysis therapy: impact of parenteral selenium supplementation.
TLDR
Selenium supplementation improves the oxygen radical scavenger system and increases selenium concentrations in plasma and erythrocytes and the activity ofselenium dependent glutathione peroxidase, and should also be considered for micronutrient supplementation in patients on chronic hemodialysis therapy.
Oxidant-antioxidant balance in granulocytes during ARDS. Effect of N-acetylcysteine.
TLDR
Parenteral NAC treatment started within 8 h of diagnosis increases the intracellular GSH in the granulocytes of ARDS patients without decreasing spontaneous oxidant production by these cells.
Vitamin E deficiency and lipoperoxidation during adult respiratory distress syndrome
TLDR
It is concluded that adult respiratory distress syndrome (ARDS) was associated with Vit E deficiency and enhancement of plasma lipoperoxidation, and the low basal values of Vit E were linked to the low cholesterol and total lipid plasma levels, probably as a consequence of malnutrition.
Increased serum catalase activity in septic patients with the adult respiratory distress syndrome.
TLDR
The findings indicate that patients with sepsis and/or ARDS have increased serum catalase activity, which may alter H2O2-dependent processes.
N-acetylcysteine in experimental and clinical acute lung injury.
  • G. Bernard
  • Medicine, Biology
    The American journal of medicine
  • 1991
Antioxidant activity of bronchoalveolar lavage fluid in the adult respiratory distress syndrome.
TLDR
The importance of both ceruloplasmin and transferrin in the enhanced AOA of ARDS BAL fluid was further demonstrated by studies that showed a significant decrement in AOA when the antioxidant functions of these two proteins were selectively blocked.
N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controlled clinical study.
TLDR
Intravenous NAC treatment during 72 h improved systemic oxygenation and reduced the need for ventilatory support in patients presenting with mild-to-moderate acute lung injury subsequent to a variety of underlying diseases.
...
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