Antioxidant roles of heme oxygenase, carbon monoxide, and bilirubin in cerebral circulation during seizures.

Abstract

Postictal cerebrovascular dysfunction is an adverse effect of seizures in newborn piglets. The brain heme oxygenase (HO) provides protection against cerebrovascular dysfunction. We investigated the contribution of reactive oxygen species (ROS) to seizure-induced vascular damage and the mechanism of HO vasoprotection. In a bicuculline model of seizures, we… (More)
DOI: 10.1038/jcbfm.2012.13

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