Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia-ischemia.

@article{Nurmi2006AntioxidantPD,
  title={Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia-ischemia.},
  author={Antti Nurmi and Gundars Goldsteins and Johanna N{\"a}rv{\"a}inen and Rea Pihlaja and Toni Ahtoniemi and Olli Gr{\"o}hn and Jari Koistinaho},
  journal={Free radical biology & medicine},
  year={2006},
  volume={40 10},
  pages={
          1776-84
        }
}
Pyrrolidine dithiocarbamate (PDTC), an antioxidant and inhibitor of transcription factor nuclear factor kappa-B (NF-kappaB), has been reported to reduce inflammation and apoptosis. Because PDTC was recently found to protect in various models of adult brain ischemia with a wide therapeutic time window, we tested the effect of PDTC in a rodent model of neonatal hypoxia-ischemia (HI) brain injury. T2-weighed magnetic resonance imaging (T2-MRI) 7 days after the insult showed that a single PDTC (50… CONTINUE READING
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