Antioxidant protection against hypochlorous acid in human plasma.

  title={Antioxidant protection against hypochlorous acid in human plasma.},
  author={M. L. Hu and S. S. -F. Louie and Carroll E. Cross and P A Motchnik and Barry Halliwell},
  journal={The Journal of laboratory and clinical medicine},
  volume={121 2},
Hypochlorous acid (HOCI) is a powerful oxidizing and chlorinating agent produced by the neutrophil enzyme myeloperoxidase. The antioxidant defenses of freshly prepared human plasma against HOCI/OCI- were explored. Addition of HOCI/OCI- to plasma caused rapid oxidation of ascorbic acid and thiol (-SH) groups but not of uric acid. Plasma -SH groups (which are known to be largely located on albumin) were quantitatively the most important scavenger of HOCI/OCI-, but adding extra ascorbate to plasma… CONTINUE READING


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