Antioxidant properties of HDL in transgenic mice overexpressing human apolipoprotein A-II.

@article{Boisfer2002AntioxidantPO,
  title={Antioxidant properties of HDL in transgenic mice overexpressing human apolipoprotein A-II.},
  author={Elisabeth Boisfer and Dominique Stengel and Dani{\`e}le Pastier and P Michel Laplaud and Nicole Dousset and Ewa Ninio and A D Kalopissis},
  journal={Journal of lipid research},
  year={2002},
  volume={43 5},
  pages={732-41}
}
Transgenic mice overexpressing human apolipoprotein A-II (huapoA-II) display high VLDL and low HDL levels. To evaluate the antioxidant potential of huapoA-II enriched HDL, we measured the activities of paraoxonase (PON) and platelet-activating factor acetylhydrolase (PAF-AH). Both activities decreased up to 43% in the serum of transgenic mice compared with controls, varied in parallel to HDL levels, but decreased less than HDL levels. The major part of PON and PAF-AH was associated with HDL… CONTINUE READING