Antioxidant properties of Ferulago angulata and its hepatoprotective effect against N-nitrosodimethylamine-induced oxidative stress in rats

  title={Antioxidant properties of Ferulago angulata and its hepatoprotective effect against N-nitrosodimethylamine-induced oxidative stress in rats},
  author={Hatice Kızıltaş and S. Ekin and M. Bayramoğlu and E. Akbaş and G. Oto and S. Yıldırım and F. Ozgokce},
  journal={Pharmaceutical Biology},
  pages={888 - 897}
Abstract Context: Ferulago angulata (Schlecht.) Boiss. (Apiaceae) (FASB) is used to treat liver diseases and has been used both as food and therapeutics by many cultures for thousands of years because of the natural antioxidant compounds. Objective: This study determines antioxidant properties of FASB flowers, the levels of minerals and vitamins, and also, evaluates the hepatoprotective effect of flowers against N-nitrosodimethylamine (NDMA) induced on liver tissue by assessing antioxidant… Expand
Nephroprotective effect of Ferulago angulata flowers on N-nitrosodimethylamine-induced nephrotoxicity in rats and its phytochemical profile.
It was found that high level of phenolic compounds present in the flower extract of F. angulata has positive effects and antioxidant properties and could protect for kidney damage and can be used as antioxidants in the food additive and pharmaceutical industry. Expand
Antioxidant and Antimicrobial Activity of Ferulago trojana
Ferulago W. Koch is a genus in the Apiaceae family comprising 34 species, of which 18 are endemic in Turkey. Ferulago species have been known since the time of Dioscorides and have been used in folkExpand
Anti-nociceptive and anti-inflammatory effects of Ferulago angulata
Introduction: Ferulago angulata from the Apiaceae family, has high flavonoid content and is detected to have anti-nociceptive and anti-inflammatory effects. Objectives: In this study, we sought toExpand
Anti-depressive effects of hydro-alcoholic extract of Chevilan ( Ferulago angulate Boiss . ) in adult male wistar rat model of ischemia / hypoperfusion
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Essential Oil Analysis and Isolation of Coumarins and Flavonol Glycosides of Ferulago angulata (Schltdl.) Boiss. Fruits
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Phytochemical evaluation of the Ferulago genus and the pharmacological activities of its coumarin constituents
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A comprehensive respect review of this interesting genus including traditional uses, chemical composition of volatile and non-volatile metabolites, and in vitro and in vivo biological properties either utilizing the crude extracts or essential oils, or the single isolated compounds. Expand
The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?
A huge protective potential inherent in plant preparations is shown, including alleviating prooxidative processes, strengthening antioxidant defence, ameliorating immune parameters, and reversing histopathological changes, which let us suggest that in the future the plant preparations could make adjuvants or a replacement for pharmaceutical agents. Expand
Variation of Chemical Constituents and Antiradical Capacity of Nine Ferulago angulata Populations from Iran
The methanolic extract of ‘Mongar’ (north‐slope at 2500 m) possessed the highest total phenolic contents, and this population logically exhibited potent antiradical activity using both 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) assays with EC50 of 42.34±0.06 %. Expand
Effects of a dietary direct-fed microbial and Ferulago angulata extract on growth performance, intestinal microflora, and immune function of broiler chickens infected with Campylobacter jejuni
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Attenuation of N-nitrosodimethylamine induced hepatotoxicity by Operculina turpethum in Swiss Albino mice
The plant extract significantly restored the antioxidant enzyme level in the liver and exhibited significant dose dependent curative effect against NDMA induced toxicity which was also supported by histopathological studies of the liver. Expand
The antioxidant activity and the bioactive compound content of Stevia rebaudiana water extracts
Stevia rebaudiana (SR), a chrysanthemum herb, has been used as a vegetable-based sweetening additive in health drinks and in other foods. This study was conducted to investigate the antioxidantExpand
In vitro antioxidant activities of methanol and aqueous extract of Annona squamosa (L.) fruit pulp.
The results obtained in the in vitro models clearly suggest that methanol extract has higher antioxidant activity than the aqueous extract due to a higher presence of phenolic and flavonodal constituents in the methano extract. Expand
Resveratrol mitigate structural changes and hepatic stellate cell activation in N'-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage.
It is concluded that antifibrotic effect of resveratrol is due to restrained oxidative damage and down-regulation of α-SMA, which inhibits HSC activation to obstruct liver fibrosis. Expand
Antioxidant, free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative cardiac cell injury.
  • M. Esmaeili, A. Sonboli
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2010
Results indicated that S. brachyantha could protect against cell injury via induction of the antioxidant enzyme defences and might be valuable antioxidant natural sources and seemed to be applicable in both healthy medicine and food industry. Expand
Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27
It is proposed that FALHE suppressed the proliferation of MCF-7 cells via cell cycle arrest and the induction of apoptosis through intrinsic pathway. Expand
Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer
Traditional Chinese medicinal plants associated with anticancer might be potential sources of potent natural antioxidants and beneficial chemopreventive agents, and contain significantly higher levels of phenolics than common vegetables and fruits. Expand
Determination of Heavy Metals Concentration in Traditional Herbs Commonly Consumed in the United Arab Emirates
The findings of the study suggest that most of the analyzed herbs contained unsafe levels of heavy metals that exceeded the World Health Organization (WHO) permissible limits (PL). Expand
The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals
Abstract Flavonoid content of mulberry leaves of 19 varieties of species, determined spectrophotometrically in terms of rutin equivalent, varied from 11.7 to 26.6 mg g −1 in spring leaves and 9.84 toExpand
Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea.
An antioxidant fraction of Chinese green tea, containing several catechins, has been previously shown to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion in mouse skin and was shown to have antioxidative activity toward hydrogen peroxide and the superoxide radical. Expand