Antioxidant network expression abrogates oxidative posttranslational modifications in mice.

@article{Mital2011AntioxidantNE,
  title={Antioxidant network expression abrogates oxidative posttranslational modifications in mice.},
  author={Rohit Mital and Wei Zhang and Ming Cai and Zachary M Huttinger and Lauren A Goodman and Debra G. Wheeler and Mark T. Ziolo and Karen M Dwyer and Anthony J. F. d'Apice and Jay L. Zweier and Guanglong He and Peter J Cowan and Richard J. Gumina},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={300 5},
  pages={H1960-70}
}
Antioxidant enzymatic pathways form a critical network that detoxifies ROS in response to myocardial stress or injury. Genetic alteration of the expression levels of individual enzymes has yielded mixed results with regard to attenuating in vivo myocardial ischemia-reperfusion injury, an extreme oxidative stress. We hypothesized that overexpression of an antioxidant network (AON) composed of SOD1, SOD3, and glutathione peroxidase (GSHPx)-1 would reduce myocardial ischemia-reperfusion injury by… CONTINUE READING
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