Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia.

  title={Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia.},
  author={Xiang-yang Zhu and Martin Rodriguez-Porcel and Michael Bentley and Alejandro R. Chade and Vincenzo Sica and Claudio Napoli and Noel M. Caplice and Erik L. Ritman and Amir Lerman and Lilach Orly Lerman},
  volume={109 17},
BACKGROUND Hypercholesterolemia (HC) and atherosclerosis can elicit oxidative stress, coronary endothelial dysfunction, and myocardial ischemia, which may induce growth-factor expression and lead to myocardial neovascularization. We tested the hypothesis that chronic antioxidant intervention in HC would attenuate neovascularization and preserve the expression of hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF). METHODS AND RESULTS Three groups of pigs (n=6… CONTINUE READING


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