Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription.

@article{Rsl1997AntioxidantinducedCO,
  title={Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription.},
  author={Frank R{\"o}sl and Bhudev Chandra Das and Maike Lengert and Karsten Geletneky and Harald zur Hausen},
  journal={Journal of virology},
  year={1997},
  volume={71 1},
  pages={362-70}
}
Considering the involvement of a redox-regulatory pathway in the expression of human papillomaviruses (HPVs), HPV type 16 (HPV-16)-immortalized human keratinocytes were treated with the antioxidant pyrrolidine-dithiocarbamate (PDTC). PDTC induces elevated binding of the transcription factor AP-1 to its cognate recognition site within the viral regulatory region. Despite of increased AP-1 binding, normally indispensable for efficient HPV-16 transcription, viral gene expression was selectively… CONTINUE READING

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