Antioxidant flavonoids from Epimedium wushanense.

  title={Antioxidant flavonoids from Epimedium wushanense.},
  author={Hui-fang Li and Xiang-yu Guan and Wen-zhi Yang and Ke-di Liu and Min Ye and Chao Sun and Shuang Lu and De-an Guo},
  volume={83 1},
Two new flavonoids, wushanicaritin (1) and wushankaempferol (2), along with 24 known flavonoids were isolated from the whole herb of Epimedium wushanense T.S. Ying (Berberidaceae). On the basis of NMR and ESI-MS spectroscopic analysis, structures of compounds 1 and 2 were elucidated as 8-γ-hydroxy-γ,γ-dimethylpropyl-3,5,7-trihydroxy-4'- methoxyflavone and kaempferol 3-O-α-l-[2,3-di-O-β-D-(6-E-p-coumaroyl) glucopyranosyl]-rhamnopyranosyl-7-O-α-L-rhamnopyranoside, respectively. DPPH radical… Expand
A new flavonol glycoside from the aerial parts of Epimedium koreanum Nakai
A new prenylated flavonol glycoside was isolated from a 95% methanol extract of the dried and powdered aerial parts of Epimedium koreanum Nakai, along with seven previously known flavonoids, and the antioxidant activities of these compounds were determined by the DPPH free radical scavenging assay. Expand
Anti-radical flavonol glycosides from the aerial parts of Cleome chelidonii L.f.
The DPPH radical scavenging properties of the flavonoid glycosides were studied in order to appreciate the effect of the glycoside parts and of the ester groups on this activity compared with the quercetin and kaempferol aglycones. Expand
Flavonoids from Epimedium pubescens: extraction and mechanism, antioxidant capacity and effects on CAT and GSH-Px of Drosophila melanogaster
Flavonoids of E. pubescens showed great potential for becoming a natural antioxidant because of their antiradical ability and effects on CAT and GSH-Px of the model organism. Expand
Flavonoid glycosides isolated from Epimedium brevicornum and their estrogen biosynthesis-promoting effects
The results suggested that the isoprenylated flavonoids from E. brevicornum may produce beneficial health effects through the promotion of estrogen biosynthesis, and PDE5 warrants further investigation as a new therapeutic target for testosterone biosynthesis in the prevention and treatment of estrogen-deficiency related diseases. Expand
Evaluation and prediction of the antioxidant activity of Epimedium from multi-wavelength chromatographic fingerprints and chemometrics
Epimedium herbs are commonly used as herbal medicine ingredients in China. In this study, firstly the total phenolic content and total flavonoid content (TFC) of Epimedium extracts were determined,Expand
Extraction, antioxidant and antimicrobial activities of Epimedium acuminatum Franch. polysaccharide.
Polysaccharides from Epimedium acuminatum were extracted by hot water and optimized with response surface methodology, and EAP60-1 with molecular weight of 114,667 Da was found to exhibit significant antihemolytic activity and antimicrobial activity. Expand
2-Phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production.
Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5-16) were isolated from the CH2Cl2-soluble fraction of a methanol extract of Epimedium koreanum.Expand
Chemical constituents from Epimedium koreanum Nakai and their chemotaxonomic significance
This is the first report of compounds 2, 3, 4 and 9 in E. koreanum and of compounds 5 and 7 in the family Berberidaceae and the chemotaxonomic significance of the isolated compounds is discussed. Expand
Chemical Constituents, Quality Control, and Bioactivity of Epimedii Folium (Yinyanghuo).
In this review, the studies conducted in the last decade about the chemical constituents, quality control, and bioactivity of Yinyanghuo are summarized and discussed. Expand
Structural characterization and antioxidant activities of polysaccharides extracted from Epimedium acuminatum.
Antioxidant assay indicated that four polysaccharides exhibited significant antioxidant activities in a dose-dependent manner, which might be used as potential natural antioxidant in E. acuminatum. Expand


Chemical Constituents from the Leaves of Epimedium sagittatum
The chemical constituents in the leaves of Epimedium sagittatum were investigated with column chromatography. Eight flavonoids, including kaempferol (1), kaempferol 3-O-α-L-rhamnopyranoside (2),Expand
[Comparison of antioxidative and antitumor activities of six flavonoids from Epimedium koreanum].
The antitumor activity of E. koreanum may be partially related to the antioxidantive activity of flavonoids, and compounds I, II, V and VI could inhibit the proliferation of MCF-7 and HepG2 in dose-dependant manner, but compounds III and IV had no effect on the proliferation. Expand
Prenylflavonol, acylated flavonol glycosides and related compounds from Epimedium sagittatum.
The results indicated that the n-BuOH extract of E. sagittatum produced a partial endothelial nitric oxide-dependent vasorelaxation, with EC(50) of 0.16+/-0.03 mg/ml, however, the 13 compounds tested, generated only a mild or moderate relaxation, and did not possess significant vasore laxing effect individually. Expand
Flavonol glycosides in the roots of Epimedium diphyllum
Two new 8-y,y-dimethylallylkaempferol glycosides, diphyllosldes A and B, were isolated from the roots and rhizomes of Eptmedium diphyllum m addition to four known flavonol glycosldes Their structuresExpand
[Chemical constituents of Epimedium wanshanense S. Z. He et Guo].
Five flavonoids were isolated from Epimedium wanshanense and identified as sagittatoside B, anhydroicaritin-3-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-rhamnopyranoside, sagittatoside A, ikarisosideExpand
Kaempferol-3-O-glucosyl(1-2)rhamnoside from Ginkgo biloba and a reappraisal of other gluco(1-2, 1-3 and 1-4)rhamnoside structures.
The NMR distinctions of 1-2, 1-3 and 1-4 linked glucopyranosylrhamnopyranusides are discussed and indicate that the 13C NMR assignments for one published gluco(1-3)rhamnoside are in need of modification. Expand
Flavonol glycosides fromEpimedium wushanense
Abstract A novel flavonol glycoside was isolated from the aerial parts of Epimedium wushanense along with nine known flavonols; icariin, baohuoside-VI, rouhuoside, quercetin 3-galactoside andExpand
Chemical constituents of roots of Epimedium wushanense and evaluation of their biological activities
Antibacterial experiment has shown that the diphyllosid A, icarisoside A and desmethylanhydroicaritin have significant activity towards Pseudomonas aeruginosa. Expand
Three flavonol glycosides from Epimedium koreanum
Abstract Three new flavonol glycosides: 4′-methoxy-5-hydroxy-8-3,3-dimethylallylflavone 3-glycosyl(1→2)rhamnoside-7-glucoside, 3-xylosyl(1→2)rhamnoside-7-glucoside andExpand
Flavonoids from Epimedium wanshanense.
A novel flavonol glycoside named wanepimedoside A was isolated from the whole plant of Epimedium wanshanense, along with fifteen known flavonoids, anhydroicaritin, desmethylanhydroicaritin, icarisidExpand