Antioxidant enzymes in ciprofibrate-induced oxidative stress.

  title={Antioxidant enzymes in ciprofibrate-induced oxidative stress.},
  author={Gursev S Dhaunsi and Inderjit Singh and John K. Orak and Avtar Kaur Singh},
  volume={15 9},
To understand the mechanism of peroxisome proliferator-induced oxidative stress in non-mutagenic carcinogenesis, the effect of ciprofibrate, a peroxisome proliferator, on the activities and protein amounts of various antioxidant enzymes in different subcellular compartments was examined. Ciprofibrate treatment for short-term (3 weeks) as well as long-term (12 weeks) duration increased the total cellular catalase activity, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPX… CONTINUE READING