Antioxidant effects on prostaglandin synthesis in rabbit kidney medulla slices

Abstract

Sodium diethyldithiocarbamate, 2,6-di-tert-butylphenol and N,N′-diphenyl-p-phenylenediamine inhibited the generation of medullary prostaglandin E, but 1,2-dimethoxyethane (OH scavenger) and 2,5-dimethylfuran (1O2 scavenger) stimulated basal prostaglandin E production 1.2–1.3-fold. These results suggest that the balance between formation and removal of cellular lipid peroxides sets a peroxide level that can regulate the rate of prostaglandin formation in cells.

DOI: 10.1007/BF01955777

Cite this paper

@article{Fujita1982AntioxidantEO, title={Antioxidant effects on prostaglandin synthesis in rabbit kidney medulla slices}, author={Tsuyoshi Fujita and Yukio Fujimoto and Hidetoshi Tanioka}, journal={Experientia}, year={1982}, volume={38}, pages={1472-1472} }