Antioxidant defense system in tissues of semiaquatic mammals

  title={Antioxidant defense system in tissues of semiaquatic mammals},
  author={T. N. Il’ina and Victor Ilyukha and Irina Baishnikova and Vladimir Belkin and Svetlana Sergina and Ekaterina Antonova},
  journal={Journal of Evolutionary Biochemistry and Physiology},
Activity of antioxidant enzymes (superoxide dismutase and catalase) and low molecular weight antioxidants (tocopherol and retinol) was studied in tissues of 8 semiaquatic mammalian species. In animals from different taxa, the enhancement of antioxidant defense can be achieved either by increased enzymatic activity of tissues or elevated concentration of low molecular weight antioxidants. The level of enzymatic and nonenzymatic (low molecular weight) antioxidants, determined in tissues and… Expand
Evolutionary Aspects of Cardioprotection
The review addresses the mechanisms of adaptation of the myocardium and cells of the cardiovascular system to hypoxia and ischemia as well as biochemical mechanisms of cardioprotection in animals ofExpand
A functional transcriptomic analysis in the relict marsupial Dromiciops gliroides reveals adaptive regulation of protective functions during hibernation
Interestingly, transcripts of thioredoxin‐interacting protein (TXNIP), a potent antioxidant, were significantly over‐expressed during torpor in all three tissues, suggesting that marsupial hibernation is a controlled process where selected metabolic pathways show adaptive modulation that can help to maintain homeostasis and enhance cytoprotection in the hypometabolic state. Expand
Divers: Air-Breathing Animals, Including Humans, at High Pressure
  • Alister Macdonald
  • Chemistry
  • Life at High Pressure
  • 2021
A wide variety of air-breathing animals temporarily suspend their normal breathing, and go under water, experiencing the hydrostatic pressure arising from depths of a few centimetres to severalExpand


Comparison between the antioxidant status of terrestrial and diving mammals.
Animals that routinely face high changes in oxygen availability and/or consumption seem to show a general strategy to prevent oxidative damage by having either appropriate high constitutive AD and or the ability to undergo arrested states, where depressed metabolic rates minimize the oxidative challenge. Expand
Antioxidant capacity develops with maturation in the deep-diving hooded seal
GSH levels along with GPx, PrxVI, Trx1, TrXR and Glrx1 activity/protein content increase with maturation, suggesting that the potential for peroxide removal increases with development in hooded seals, and that these enzymes contribute to the regulation of the intracellular redox state and the prevention of oxidative damage in these deep-diving mammals. Expand
Hypoxia tolerance in mammals and birds: from the wilderness to the clinic.
The challenge for future research is to explore the cellular mechanisms and conditions that transform an organ or a cellular network into a hypometabolic state, without loss of functional integrity. Expand
The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.
It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase. Expand
Supplementation of antioxidants prevents oxidative stress during a deep saturation dive.
The effects of supplementation of antioxidants appeared to prevent a hepatic disturbance, indicating that a deep saturation dive provokes liver dysfunction probably due to oxidative stress, and recommends that saturation divers should take supplements of antioxidants. Expand
Comparison of serum lipid compositions, lipid peroxide, alpha-tocopherol and lipoproteins in captive marine mammals (bottlenose dolphins, spotted seals and West Indian manatees) and terrestrial mammals.
The results suggest that triglyceride and phospholipid are susceptible to oxidative reaction in fish-eating animals and evaluation of serum lipids, LPO and alpha-tocopherol concentrations is needed for nutritional husbandry for fish- eating animals. Expand
Muscle senescence in short-lived wild mammals, the soricine shrews Blarina brevicauda and Sorex palustris.
It is demonstrated that age-related muscle senescence does occur in wild-caught, short-lived mammals, and this classic aging theory tenet is rejected, illustrating that differential age adjustments in contractile/connective tissue components of muscle occur in the two species of wild- caught shrews. Expand
Basal energy metabolism of mustelids
  • J. Iversen
  • Biology
  • Journal of comparative physiology
  • 2004
The high BMR observed in weasels and stoats, suggests that a metabolic adjustment has occurred in the smaller species of the mustelid family. Expand
A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.
A quantitative, spectrophotometric technique for following the breakdown of hydrogen peroxide has been developed for routine studies of catalase kinetics and appears to give lower values forCatalase activity than do titration techniques. Expand
Fasting and lactation effect fat-soluble vitamin A and E levels in blood and their distribution in tissue of grey seals (Halichoerus grypus).
Results indicate that both plasma and liver levels of vitamin A and E are affected by the mobilisation, absorption and deposition of these components during lactation in seals to a much greater extent than adipose tissue, from which fat-soluble vitamins are mobilized at rates similar to that of lipids. Expand