Antioxidant defense mechanisms of endothelial cells: glutathione redox cycle versus catalase.

@article{Suttorp1986AntioxidantDM,
  title={Antioxidant defense mechanisms of endothelial cells: glutathione redox cycle versus catalase.},
  author={Norbert Suttorp and Wolfgang T{\"o}pfer and Ladislaus Roka},
  journal={The American journal of physiology},
  year={1986},
  volume={251 5 Pt 1},
  pages={C671-80}
}
The importance of the glutathione (GSH) redox cycle and of catalase as intracellular antioxidant defense systems in cultured endothelial cells against an extracellular flux of H2O2, a critical mediator of polymorphonuclear leukocyte-induced oxidant injury of endothelial cells, was examined. The activities of different parts of the GSH redox cycle were impaired by 1,3-bis(2-chloroethyl)-1-nitrosourea, buthionine sulfoximine, diethyl maleate and 2-cyclohexene-1-one. Catalase activity was… CONTINUE READING