Antioxidant defence during cardiopulmonary bypass surgery.

  title={Antioxidant defence during cardiopulmonary bypass surgery.},
  author={Chris R Luyten and Frans J van Overveld and Lieve A De Backer and Anna M Sadowska and Inez E R Rodrigus and Stefan De Hert and Wilfried A. De Backer},
  journal={European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery},
  volume={27 4},
OBJECTIVE Cardiac surgery may lead to severe oxidative stress due to formation of oxidation products generated during ischemia and reperfusion. We investigated to which extent oxidative stress influences a number of endogenous antioxidants and markers of cellular activation. METHODS At six time points blood was withdrawn from patients undergoing coronary artery bypass grafting, using the on-pump procedure. RESULTS Both glutathione peroxidase and superoxide dismutase show a gradual and… CONTINUE READING


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