Antioxidant and vasodilatory effects of heme oxygenase on mesenteric vasoreactivity following chronic hypoxia.

@article{Sweazea2009AntioxidantAV,
  title={Antioxidant and vasodilatory effects of heme oxygenase on mesenteric vasoreactivity following chronic hypoxia.},
  author={Karen L. Sweazea and Benjimen R. Walker},
  journal={Microcirculation},
  year={2009},
  volume={16 2},
  pages={131-41}
}
OBJECTIVE Chronic hypoxia (CH) results in impaired vasoconstriction associated with increased expression of heme oxygenase (HO). We hypothesized that enhanced HO activity minimizes reactive oxygen species (ROS) in arteries from CH rats, thereby normalizing endothelium-dependent vasodilation and concurrently produces carbon monoxide (CO), resulting in tonic vasodilation. METHODS ROS were quantified in mesenteric arteries from control and CH Sprague-Dawley rats. Reactivity to the endothelium… CONTINUE READING