Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation.

@article{Kostyuk2011AntioxidantAS,
  title={Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation.},
  author={Vladimir Kostyuk and Alla I. Potapovich and Tatyana O. Suhan and Chiara Maria Giulia De Luca and Liudmila Korkina},
  journal={European journal of pharmacology},
  year={2011},
  volume={658 2-3},
  pages={
          248-56
        }
}
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82 Citations
Highly Influential Citations
1
Background Citations
31
Methods Citations
2
Results Citations
1

82 Citations

Proatherogenic macrophage activities are targeted by the flavonoid quercetin.
TLDR
It is demonstrated that quercetin interferes with both key proatherogenic activities of macrophages, namely foam cell formation and pro-oxidant/proinflammatory responses, and these effects may explain the atheroprotective properties of this common flavonoid.
At the interface of antioxidant signalling and cellular function: Key polyphenol effects
TLDR
The molecular mechanisms for 3 actions of (poly)phenols on oxidative processes where there is evidence in vivo from human intervention or animal studies are reviewed.
Role of GPx4 in human vascular endothelial cells, and the compensatory activity of brown rice on GPx4 ablation condition.
Immunomodulatory Properties of Polyphenol-Rich Sugarcane Extract on Human Monocytes
TLDR
PRSE exerts an immunomodulatory effect on U937 monocytes in vitro, potentially facilitating the conversion from inflammation to healing, and is likely to be independent of the NF-κB signalling pathway, suggesting that other mechanisms drive this effect.
Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-κB Inhibition in THP-1 Monocytes
TLDR
It is demonstrated that BJe inhibited both gene expression and secretion of LPS-induced pro-inflammatory cytokines by a mechanism involving the inhibition of NF-κB activation, and increasing concentrations of Sirtinol were able to suppress the inhibitory effect of BJe via p65 acetylation, underscoring that NF-γB–mediated inflammatory cytokine production may be directly linked to SIRT1 activity.
Polyphenols Suppress and Modulate Inflammation
Immunomodulatory Effects of Dietary Polyphenols
TLDR
Polyphenols have a potential role in prevention/treatment of auto-immune diseases like type 1 diabetes, rheumatoid arthritis and multiple sclerosis by regulating signaling pathways, suppressing inflammation and limiting demyelination.
Multifunctional targets of dietary polyphenols in disease: a case for the chemokine network and energy metabolism.
  • J. Joven, A. Rull, J. Menéndez
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2013
Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR-ERK pathway.
Longxuetongluo capsule inhibits atherosclerosis progression in high-fat diet-induced ApoE-/- mice by improving endothelial dysfunction.
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TLDR
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