Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation.

  title={Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation.},
  author={Vladimir Kostyuk and Alla I. Potapovich and Tatyana O. Suhan and Chiara Maria Giulia De Luca and Liudmila Korkina},
  journal={European journal of pharmacology},
  volume={658 2-3},
Proatherogenic macrophage activities are targeted by the flavonoid quercetin.
It is demonstrated that quercetin interferes with both key proatherogenic activities of macrophages, namely foam cell formation and pro-oxidant/proinflammatory responses, and these effects may explain the atheroprotective properties of this common flavonoid.
At the interface of antioxidant signalling and cellular function: Key polyphenol effects
The molecular mechanisms for 3 actions of (poly)phenols on oxidative processes where there is evidence in vivo from human intervention or animal studies are reviewed.
Role of GPx4 in human vascular endothelial cells, and the compensatory activity of brown rice on GPx4 ablation condition.
Immunomodulatory Properties of Polyphenol-Rich Sugarcane Extract on Human Monocytes
PRSE exerts an immunomodulatory effect on U937 monocytes in vitro, potentially facilitating the conversion from inflammation to healing, and is likely to be independent of the NF-κB signalling pathway, suggesting that other mechanisms drive this effect.
Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-κB Inhibition in THP-1 Monocytes
It is demonstrated that BJe inhibited both gene expression and secretion of LPS-induced pro-inflammatory cytokines by a mechanism involving the inhibition of NF-κB activation, and increasing concentrations of Sirtinol were able to suppress the inhibitory effect of BJe via p65 acetylation, underscoring that NF-γB–mediated inflammatory cytokine production may be directly linked to SIRT1 activity.
Immunomodulatory Effects of Dietary Polyphenols
Polyphenols have a potential role in prevention/treatment of auto-immune diseases like type 1 diabetes, rheumatoid arthritis and multiple sclerosis by regulating signaling pathways, suppressing inflammation and limiting demyelination.
Multifunctional targets of dietary polyphenols in disease: a case for the chemokine network and energy metabolism.
  • J. Joven, A. Rull, J. Menéndez
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2013


Attenuation of monocyte adhesion and oxidised LDL uptake in luteolin-treated human endothelial cells exposed to oxidised LDL
The results demonstrate that the flavones luteolin and apigenin as well as quercetin were effective in the different initial steps of atherosclerosis process by inhibiting oxidising LDL-induced endothelial monocyte adhesion and/or oxidised LDL uptake.
Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids.
It is suggested that dietary flavonoids may have therapeutic potential for protecting the endothelium from oxidative stress and oxidized LDL-triggered atherogenesis and promote cell survival as potent antioxidants.
The role of oxidized lipoproteins in atherogenesis.
Immunoregulatory effects of the flavonol quercetin in vitro and in vivo
Quercetin reduced DC adhesion and oxLDL-induced DC differentiation and reduced circulating plasmacytoid DCs and systemic ADMA-levels in vitro and in vivo and may contribute to the anti-atherosclerotic potential of flavonols.
Olive Oil and Red Wine Antioxidant Polyphenols Inhibit Endothelial Activation: Antiatherogenic Properties of Mediterranean Diet Phytochemicals
Olive oil and red wine antioxidant polyphenols at nutritionally relevant concentrations transcriptionally inhibit endothelial adhesion molecule expression, thus partially explaining atheroprotection from Mediterranean diets.
The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets.
In human platelets, phloretin diminished adenosine diphosphate (ADP) and thrombin receptor-activating peptide-stimulated expression of the activated form of the GPIIb/IIIa complex and reduced platelet aggregation stimulated by ADP.
Dietary flavonoids differentially reduce oxidized LDL-induced apoptosis in human endothelial cells: role of MAPK- and JAK/STAT-signaling.
Evidence is provided that the interplay between p38MAPK and JAK-STAT pathways is involved in dietary flavonoid protection against oxidized LDL through hampering MAPK-dependent pathways involving the activation of JAK2.