Antioxidant and prooxidant properties of captopril and enalapril.

@article{Bartosz1997AntioxidantAP,
  title={Antioxidant and prooxidant properties of captopril and enalapril.},
  author={Małgorzata Bartosz and J{\'o}zef Kȩdziora and Grzegorz Bartosz},
  journal={Free radical biology \& medicine},
  year={1997},
  volume={23 5},
  pages={
          729-35
        }
}

Effect of captopril on mushroom tyrosinase activity in vitro.

Interactions between carnosine and captopril on free radical scavenging activity and angiotensin-converting enzyme activity in vitro.

The data suggest that carnosine in its concurrent use with captopril could act as a beneficial free radical scavenger, with less danger of overdose, in the inhibition of ACE activity.

Protective effects of captopril against ischemic stress: role of cellular Mg.

The data suggest that Mg influences the cellular response to ischemia and that the ability of SH compounds such as captopril to ameliorate ischemic injury may at least in part be attributable to the able of such compounds to increase cytosolic free Mg levels.

Characterization of the reaction products, kinetics and mechanism of oxidation of the drug captopril by platinum(IV) complexes

The rate constants for the rate-determining steps have been derived, demonstrating that the fully deprotonated captopril is about 105 to 106 times more reactive than its corresponding thiol form toward the Pt(IV) complexes.

DOES CAPTOPRIL CHANGE OXIDATIVE STRESS IN PUROMYCIN AMINONUCLEOSIDE NEPHROPATHY?

Data suggest that PAN changes the antioxidative factor pattern in rat blood and kidney and only to a certain extent modifies these effects showing protective effect only on tissue catalase activity.

Chemoprotective effects of captopril against cyclophosphamide-induced genotoxicity in mouse bone marrow cells

It appears that CAP, due to its antioxidant activity and by increasing GSH levels, can modulate the reduced cellular thiol content induced by CP and reduce the genotoxicity of CP in bone marrow cells.

Effect of spironolactone and captopril on nitric oxide and S-nitrosothiol formation in kidney of L-NAME-treated rats.

Both captopril and spironolactone prevented L-NAME-induced hypertension and the decline of the antioxidant potential of the kidney tissue, however, only spironOLactone improved NOS activity which led to the S-nitrosothiols formation.
...

References

SHOWING 1-10 OF 31 REFERENCES

Does captopril attenuate reperfusion‐induced myocardial dysfunction by scavenging free radicals?

Results indicate that captopril scavenges superoxide anions in vitro independent of an action on ACE, which is probably related to the presence of a sulfhydryl moiety.

The Autoxidation of Human Red Cell Lipids Induced by Hydrogen Peroxide

Lack of reproducibility, a feature of previous methods of measuring the susceptibility of red cells to exogenous peroxide, could be overcome by (i) catalase inhibition, (ii) attention to the non‐linear relation between packed‐cell volume and MDA formation, and (iii) elimination of potentially misleading coloured complexes on spectroscopy.

Evaluation of the antioxidant properties of the angiotensin-converting enzyme inhibitor, captopril and the nucleotide enhancing agent, acadesine.

  • M. WasilF. Kelly
  • Biology
    Redox report : communications in free radical research
  • 1995
The antioxidant potential of captopril and acadesine may be an important component of their mechanism of action, with both drugs probably protecting the myocardium against oxygen derived free radicals during ischaemia/reperfusion.