Antioxidant and neuroprotective properties of N-arachidonoyldopamine

@article{Bobrov2008AntioxidantAN,
  title={Antioxidant and neuroprotective properties of N-arachidonoyldopamine},
  author={Mikhail Yu Bobrov and A. A. Lizhin and Ekaterina L. Andrianova and Natalia Gretskaya and Lidia E. Frumkina and Leonid G. Khaspekov and Vladimir V Bezuglov},
  journal={Neuroscience Letters},
  year={2008},
  volume={431},
  pages={6-11}
}
N-Arachidonoyl Dopamine: A Novel Endocannabinoid and Endovanilloid with Widespread Physiological and Pharmacological Activities
TLDR
Findings provide strong evidence that NADA is an effective agent to manage neuroinflammatory diseases or pain and can be useful in designing novel therapeutic strategies.
Efficient N-Acyldopamine Synthesis.
TLDR
The eighteen potentially endogenous N-acyldopamines and two deuterated ones, N-palmitoyl dopamine-d5 and N-stearoyL dopamine- d5, were efficiently synthesized without protective groups in CH2Cl2 under optimized conditions using propylphosphoric acid cyclic anhydride (PPACA) as a condensation agent.
Influence of N-Arachidonoyl Dopamine and N-Docosahexaenoyl Dopamine on the Expression of Neurotrophic Factors in Neuronal Differentiated Cultures of Human Induced Pluripotent Stem Cells under Conditions of Oxidative Stress
Oxidative stress (OS) is implicated in the pathogenesis of several neurodegenerative diseases. We have previously shown that N-acyl dopamines (N-ADA and N-DDA) protect the neural cells of healthy
Opposite effects of anandamide and n‐arachidonoyl dopamine in the regulation of prostaglandin E2 and 8‐iso‐PGF2α formation in primary glial cells
TLDR
This study examines the role of two endocannabinoids, anandamide (AEA) and N‐arachidonoyldopamine (NADA) in the regulation of prostaglandin E2 (PGE2) synthesis in primary glial cells and describes NADA as a potential antioxidative and anti‐inflammatory agent acting through a mechanism that involves reduction in the synthesis of microsomal prostaglandsin E synthase in LPS‐activated microglia.
Neuroprotective properties of endocannabinoids N-arachidonoyl dopamine and N-docosahexaenoyl dopamine examined in neuronal precursors derived from human pluripotent stem cells
Neuroprotective properties of endocannabinoids N-arachidonoyl dopamine (NADA) and N-docosahexaenoyl dopamine (DHDA) were examined in neuronal precursor cells differentiated from human induced
The Endocannabinoid/Endovanilloid N-Arachidonoyl Dopamine (NADA) and Synthetic Cannabinoid WIN55,212-2 Abate the Inflammatory Activation of Human Endothelial Cells*
TLDR
It is demonstrated that the synthetic cannabinoid WIN55,212-2 and the eCB N-arachidonoyl dopamine (NADA) reduce EC inflammatory responses induced by bacterial lipopeptide, LPS, and TNFα, and may have important implications for a variety of acute inflammatory disorders that are characterized by EC activation.
Immunosuppressive and anti‐inflammatory effects of N‐acyl dopamines on Con A‐stimulated splenocytes of BALB/c mouse
TLDR
The findings suggest that N-acyl dopamines may express immuno-modulatory action through pathways involving CB1 and TRPV1 receptors in splenocytes through pathways involved in the regulation of inflammation and immunomodulation in BALB/c mice.
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References

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N-Oleoyldopamine, a Novel Endogenous Capsaicin-like Lipid That Produces Hyperalgesia*
N-Arachidonoyldopamine (NADA) was recently identified as an endogenous ligand for the vanilloid type 1 receptor (VR1). Further analysis of the bovine striatal extract from which NADA was isolated
Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1
TLDR
The results strongly suggest that CB1 is not involved in the cellular antioxidant neuroprotective effects of cannabinoids, and the role of CB1 in neuroprotection is elucidated.
Neuroprotection by the Endogenous Cannabinoid Anandamide and Arvanil against In Vivo Excitotoxicity in the Rat: Role of Vanilloid Receptors and Lipoxygenases
TLDR
This study assessed whether VR1 is involved in neuroprotection by AEA and by arvanil, a hydrolysis-stable AEA analog that is a ligand for both VR1 and CB1, and the putative involvement of lipoxygenase metabolites of AEA in conveying neuroprotection.
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TLDR
The antioxidant and free radical scavenging effects of dopamine, noradrenaline, tyramine, and tyrosine were investigated and compared with alpha-tocopherol and the results for reducing power and scavenging effect had a similar trend as their inhibition of linoleic acid peroxidation.
Immunosuppressive Activity of Endovanilloids: N-Arachidonoyl-Dopamine Inhibits Activation of the NF-κB, NFAT, and Activator Protein 1 Signaling Pathways 1
TLDR
The immunosuppressive activity of NADA and N-oleoyldopamine in human T cells is evaluated, discovering that both compounds are potent inhibitors of early and late events in TCR-mediated T cell activation.
Mechanisms of HIV-1 Inhibition by the Lipid Mediator N-Arachidonoyldopamine1
TLDR
The anti-HIV-1 activity of NADA was independent of known cannabinoid and vanilloid receptor activation and did not affect reverse transcription and integration steps of the viral cycle, and its inhibitory effect was additive with that of the reverse transcriptase inhibitor azidothymidine.
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
TLDR
The hypothesis, based on previous structure-activity relationship studies and the availability of biosynthetic precursors, that N-arachidonoyl-dopamine (NADA) is an endogenous “capsaicin-like” substance in mammalian nervous tissues is examined and found that NADA occurs in nervous tissues.
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