Antioxidant and neuroprotective effects of synthesized sintenin derivatives.


Three series of sintenin derivatives (compounds 1-14) were designed and prepared and their antioxidative and neuroprotective effects were evaluated. The in vitro models of scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, chelating ferrous ions, inhibiting the rat brain homogenates lipid peroxidation, and protecting neurons damaged by hydrogen peroxide were employed for bioassays. It was found that sintenin derivatives 4 and 13 showed remarkable antioxidative and neuroprotective activities.

DOI: 10.1080/14756360802188214

Cite this paper

@article{Yang2009AntioxidantAN, title={Antioxidant and neuroprotective effects of synthesized sintenin derivatives.}, author={Lei Yang and Lu-yin Zhang and Ke Xin Huang and Xiao Kun Li and Li Hong Hu and Xiao Yu May Wang and Joachim Stockigt and Yu Zhao}, journal={Journal of enzyme inhibition and medicinal chemistry}, year={2009}, volume={24 2}, pages={425-31} }