Antioxidant and mitochondrial protective effects of silibinin in cold preservation-warm reperfusion liver injury.

@article{Ligeret2008AntioxidantAM,
  title={Antioxidant and mitochondrial protective effects of silibinin in cold preservation-warm reperfusion liver injury.},
  author={Heidi Ligeret and Antoine Brault and Diane Vallerand and Yara Haddad and Pierre S. Haddad},
  journal={Journal of ethnopharmacology},
  year={2008},
  volume={115 3},
  pages={507-14}
}
AIM OF THE STUDY Silybum marianum (milk thistle) is a Mediterranean plant that has been used since Greco-Roman times to treat liver ailments. Silibinin, the most active hepatoprotective constituent of the plant's seed, possesses antioxidant and anti-inflammatory properties. We thus assessed its protective potential in liver transplantation injury. MATERIALS AND METHODS Rat livers were isolated and preserved during 24h at 4 degrees C in University of Wisconsin (UW) solution alone (control), UW… CONTINUE READING