Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures.

@article{Morel1993AntioxidantAI,
  title={Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures.},
  author={Isabelle Morel and G{\'e}rard Lescoat and P Cogrel and Odile Sergent and Nicole Pasdeloup and Pierre Brissot and Pierre Cillard and Josiane Cillard},
  journal={Biochemical pharmacology},
  year={1993},
  volume={45 1},
  pages={
          13-9
        }
}
The cytoprotective effect of three flavonoids, catechin, quercetin and diosmetin, was investigated on iron-loaded hepatocyte cultures, considering two parameters: the prevention of iron-increased lipid peroxidation and the inhibition of intracellular enzyme release. These two criteria of cytoprotection allowed the calculation of mean inhibitory concentrations (IC50) which revealed that the effectiveness of these flavonoids could be classified as follows: catechin > quercetin > diosmetin. These… Expand
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