• Corpus ID: 7731134

Antioxidant and hypoglycemic effects of Tithonia diversifolia aqueous leaves extract in alloxan-induced diabetic mice

@article{Thongsom2013AntioxidantAH,
  title={Antioxidant and hypoglycemic effects of Tithonia diversifolia aqueous leaves extract in alloxan-induced diabetic mice},
  author={Montakarn Thongsom and Warangkana Chunglok and Rapeeporn Kuanchuea and Jitbanjong Tangpong},
  journal={Advances in Environmental Biology},
  year={2013},
  pages={2116-2126}
}
Diabetes is a chronic disease cause the metabolic disorder and associated with serious complications. Various studies have shown that diabetes mellitus is associated with increased the formation of free radicals and decreased antioxidant potential. Oxidative stress is increased in diabetes because of multiple factors. Dominant among these factors is glucose autoxidation leading to the production of free radicals. Treatment with the antioxidants may play an important role in the improvement of… 

Figures and Tables from this paper

Ethanol Extract of Tithonia diversifolia (Hemsley) A Gray Standardized Ameliorates Hyperglycemia, Polyphagia, and Weight Loss in Diabetic Rats
TLDR
Tithonia diversifolia ethanolic extract has anti-hyperglycemic effect and ameliorated the effect of diabetes mellitus symptoms, namely polyphagia and weight loss.
Antihyperglycemic Activity of Aqueous Extract of Insulin Leaves (Tithonia diversifolia) on Hyperglycemic Rats (Rattus norvegicus)
Insulin leave (Tithonia diversifolia (Hemsl.) A. Gray) empirically used by people as antihyperglycemic drugs. The study was aimed to evaluate antihyperglycemic activity as well as to determine the
The influence of ethanol extract and variety of fraction from Tithonia Diversifolia on blood glucose level of male white mice
Tithonia diversifolia have properties of insulin to lower blood glucose levels, such as phenolic compounds, terpenoids and flavonoids. This study aimed to anti-hyperglicemic activity of ethanol
Effect of Boiled Water Tithonia diversifolia A. Gray Leaf Against the Pancreas Histology in Mus musculus L. Induced by Alloxan
TLDR
Results showed that administration of boiled kembang bulan leaves and metformin for 7 days could reduce blood sugar levels in mice and accelerate the regeneration of pancreatic β cells.
Allelopathy as a Factor of Improving Anti-hyperglycaemic Activities of Tithonia diversifolia and Murraya koenigii
Tithonia diversifolia (Tithonia), with allelopathic activity report, and Murraya koenigii (Curry) are used ethnomedicinally as antidiabetics in Nigeria. Separately established one week old shoots of
Variation of biochemical and antioxidant activity with respect to the phenological stage of Tithonia diversifolia Hemsl. (Asteraceae) populations
TLDR
It is indicated that phytochemical and antioxidant variations between populations are influenced by genetic factors as well as environmental conditions.
Comparative Antidiabetic Potential and Survival Function of Harungana madagascariensis, Physalis peruviana, Solanum americanum and Tithonia diversifolia Extracts on Alloxan-Induced Diabetes in Guinea-Pigs
Background-The World Health Organization recommends promoting traditional alternative herbal therapies in poor countries because modern drugs are out of reach for many populations. Objective-This
An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology.
TLDR
An in-depth understanding on the pharmacology and toxicology of Gabonese anti-diabetic plants is lacking yet there is a great scope for new treatments.
Antioxidant and Cytotoxic Activity of the Leaf Ethanolic Extracts of Tithonia diversofilia and Gliricidia sepium from Bukidnon, Philippines
TLDR
The results indicate that the detected phytochemicals may account for the exhibited biological activities of T. diversifolia that warrants further investigation.
Pharmacological Profile of Tithonia diversifolia (Hemsl) A. Gray: A Comprehensive Review
TLDR
This review aims to provide an up-to-date overview of pharmacological studies of Tithonia diversifolia (Hemsl.) A.Gray and to suggest future investigations into its possible exploitation to treat different diseases and to fully understand the mode of action of the active constituents.
...
1
2
3
...

References

SHOWING 1-10 OF 49 REFERENCES
Potential antidiabetic and antioxidant activities of Morus indica and Asystasia gangetica in alloxan-induced diabetes mellitus
TLDR
The present study provides a scientific evidence for antidiabetic and antioxidant potential of Asystasia gangetica and Morus indica and further studies to isolate bioactive compounds will pave the way to identify potential lead compounds for developing safe and efficacious antidi diabetic agents.
Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property.
TLDR
Methanolic extract of Terminalia chebula, Terminalia belerica, Emblica officinalis and their combination named 'Triphala' (equal proportion of above three plant extracts) were found to inhibit lipid peroxide formation and to scavenge hydroxyl and superoxide radicals in vitro.
ANTIDIABETIC AND ANTIHYPERGLYCAEMIC EFFECTS OF NEEM SEEDS KERNEL POWDER ON ALLOXAN DIABETIC RABBITS
Objective: To study the effects of neem kernel powder(NP) and glibenclamide. alone or in combination, on alloxan diabetic rats. Methods: The diabetic rabbits were given with NP alone or in
Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes
Abstract Oxidative stress is a common pathogenesis of diabetes mellitus and asiatic acid (AA) plays an important role in ameliorating those difficulties. The present study was designed the protective
In vitro and In vivo Antioxidant Activity of Aphanamixis polystachya Bark
TLDR
Due to its natural origin and potent free-radical scavenging ability A. polystachya could be used as a potential preventive intervention for free radical-mediated diseases.
Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract.
TLDR
The results of the present study further confirm the use of Tithonia diversifolia traditionally for the treatment of painful inflammatory conditions.
ANTIDIABETIC AND ANTIOXIDATIVE EFFECTS OF AQUEOUS EXTRACT OF SEED OF PSORALEA CORYLIFOLIA (SOMRAJI) AND SEED OF TRIGONELLA FOENUM-GRAECUM L. (METHI) IN SEPARATE AND COMPOSITE MANNER IN STREPTOZOTOCIN-INDUCED DIABETIC MALE ALBINO RAT
TLDR
Composite extract of above plants parts have more potential antidiabetogenic activities than separate and a significant recovery in the activities of above mention enzymes along with correction in fasting glucose level in composite extract treated diab etic group than the individual extract treated diabetic group.
Diabetes mellitus: an overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity.
TLDR
The information provided in this review will help the researchers for the development of an alternative methods rather than insulin and oral hypoglycemic agents for the treatment of diabetes mellitus, which will minimize the complication associated with the diabetes and related disorder.
Protective effects of moderate exercise with dietary vitamin C and E on blood antioxidative defense mechanism in rats with streptozotocin-induced diabetes.
TLDR
Data demonstrate an increase in LP in the blood of diabetic animals whereas there was a decrease in the antioxidant vitamins and enzymes, however, dietary VCE with moderate exercise may strengthen the antioxidant defense system by decreasing reactive oxygen species.
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.
TLDR
The cytotoxic action of both these diabetogenic agents is mediated by reactive oxygen species, however, the source of their generation is different in the case of alloxan and streptozotocin.
...
1
2
3
4
5
...