Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia

@article{Ragino2008AntioxidantAE,
  title={Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia},
  author={Yu. I. Ragino and V. A. Vavilin and Nariman F. Salakhutdinov and S. I. Makarova and Ekaterina Mikhailovna Stakhneva and O. G. Safronova and Vyacheslav V. Lyakhovich and Yu. P. Nikitin and Genrich A. Tolstikov},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2008},
  volume={146},
  pages={206-209}
}
Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 µg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27–41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26–58 and 21–29%, respectively, compared to 200 µg/kg simvastatin, p<0.05). 
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