Antioxidant and antiviral activities of silybin fatty acid conjugates.

  title={Antioxidant and antiviral activities of silybin fatty acid conjugates.},
  author={R Gazak and Kateřina Purchartov{\'a} and Petr Marhol and Lucie Zivn{\'a} and Petr Sedmera and Kateřina Valentov{\'a} and Nobuo Kato and Hiroyo Matsumura and Kunihiro Kaihatsu and Vladim{\'i}r Křen},
  journal={European journal of medicinal chemistry},
  volume={45 3},
Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety. 
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