Antioxidant and antiproliferative activity of curcumin semicarbazone.

  title={Antioxidant and antiproliferative activity of curcumin semicarbazone.},
  author={Sabari Dutta and Subhash Balkrishna Padhye and Kavirayani Indira Priyadarsini and Chris R. Newton},
  journal={Bioorganic & medicinal chemistry letters},
  volume={15 11},
A new semicarbazone derivative of curcumin (CRSC) was synthesized and examined for its antioxidant, antiproliferative, and antiradical activity and compared with those of curcumin (CR). The antioxidant activity was tested by their ability to inhibit radiation induced lipid peroxidation in rat liver microsomes. The antiproliferative activity was tested by studying the in vitro activity of CRSC against estrogen dependant breast cancer cell line MCF-7. Kinetics of reaction of (2,2'-diphenyl-1… CONTINUE READING


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