Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models.

@article{Parhiz2015AntioxidantAA,
  title={Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models.},
  author={Hamideh Parhiz and Ali Roohbakhsh and Fatemeh Soltani and Ramin Rezaee and Mehrdad Iranshahi},
  journal={Phytotherapy research : PTR},
  year={2015},
  volume={29 3},
  pages={
          323-31
        }
}
Inflammation and oxidative stress are two major causes of various life-threatening diseases. Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species that have numerous biological properties, particularly antioxidant and anti-inflammatory. New findings showed that the antioxidant activity of Hsd/Hst was not only limited to its radical scavenging activity, but it augmented the antioxidant cellular defenses via the ERK/Nrf2 signaling pathway as well. Various in… CONTINUE READING
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