Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae

@article{Romay1998AntioxidantAA,
  title={Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae},
  author={Cheyla Romay and Julio Armesto and Diadelis Rem{\'i}rez and Ricardo Gonz{\'a}lez and Nurys Led{\'o}n and Irene Salmer{\'o}n Garc{\'i}a},
  journal={Inflammation Research},
  year={1998},
  volume={47},
  pages={36-41}
}
Abstract.Objective: Phycocyanin is a pigment found in blue-green algae which contains open chain tetrapyrroles with possible scavenging properties. We have studied its antioxidant properties.¶Materials and methods: Phycocyanin was evaluated as a putative antioxidant in vitro by using: a) luminol-enhanced chemiluminescence (LCL) generated by three different radical species (O−2, OH•, RO•) and by zymosan activated human polymorphonuclear leukocytes (PMNLs), b) deoxyribose assay and c) inhibition… 
C-phycocyanin: a potent peroxyl radical scavenger in vivo and in vitro.
TLDR
It is demonstrated that phycocyanin is a potent peroxyl radical scavenger with an IC(50) of 5.0 microM and the rate constant ratios obtained for phydynamic acid and uric acid were 1.54 and 3.5, respectively, which clearly suggest that the covalently linked chromophore, phyCocyanobilin, is involved in the antioxidant and radical scavenging activity of phy cokyanin.
Antioxidant and Anti-Inflammatory Properties of an Aqueous Cyanophyta Extract Derived from Arthrospira Platensis: Contribution to Bioactivities by the Non-Phycocyanin Aqueous Fraction
TLDR
Both PC and the non-PC fraction contributed to the antioxidant properties and anti-inflammatory effects, without a negative impact on blood clotting in vitro, suggesting a potential benefit for the consumable ACE extract in assisting the reduction of inflammatory conditions.
Salubrious effect of C-phycocyanin against oxalate-mediated renal cell injury.
Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation
TLDR
Phycocyanin shows anti-inflammatory activity in four experimental models of inflammation and may contribute, at least in part, to its anti- inflammation activity.
The Therapeutic Effect and the Possible Mechanism of C-Phycocyanin in Lipopolysaccharide and Seawater-Induced Acute Lung Injury
TLDR
C-PC significantly alleviated pathological damages, suppressed oxidative stress, inflammation and apoptosis, and enhanced the viability of epithelial cells in the lung tissues, providing new insight into ALI/ARDS treatment.
Oxygen radical absorbance capacity of phycocyanin and phycocyanobilin from the food supplement Aphanizomenon flos-aquae.
TLDR
The ORAC method was applied to investigate the capacity of PC and PCB purified from the edible microalga Aphanizomenon flos-aquae to directly quench peroxyl radicals in comparison to well-known antioxidants molecules such as Trolox, ascorbic acid, and reduced glutathione and found PCB to have the highest ORAC value.
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