Antioxidant and alpha-glucosidase inhibitory activities of isoflavonoids from the rhizomes of Ficus tikoua Bur

@article{Fu2018AntioxidantAA,
  title={Antioxidant and alpha-glucosidase inhibitory activities of isoflavonoids from the rhizomes of Ficus tikoua Bur},
  author={Guang-miao Fu and Wen-Juan Li and Xiang-zhong Huang and Runzhi Zhang and Kai Tian and Shu-Qun Hou and Yukui Li},
  journal={Natural Product Research},
  year={2018},
  volume={32},
  pages={399 - 405}
}
Abstract A new unique isoflavone derivatives with a cyclic-monoterpene-substituent, ficusin C (1), together with five known compounds (2–6), were isolated from the rhizomes of Ficus tikoua. Their structures were elucidated on the basis of spectroscopic data interpretation, mass spectrometric analysis and comparison with literature data of related compounds. Antioxidant and α-glucosidase inhibitory activities of these compounds were evaluated by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical… 

A new isoflavone from the fruits of Ficus auriculata and its antibacterial activity

TLDR
A new isoflavone (Z)-5,7,4'-trihydroxy-3'-[3-hydroxy -3-methyl-1-butenyl] is oflavone together with seven known isofavones (2-8) were isolated from the fruits of the Ficus auriculata for antibacterial activities against pathogenic bacteria in vitro.

A new hemiacetal chromone racemate and α-glucosidase inhibitors from Ficus tikoua Bur.

From the petroleum ether and ethyl acetate portions of the 95% ethanol extract of Ficus tikoua Bur., a new hemiacetal chromone racemate, named (±)-ficunomone (1), together with twenty-two known

Chemical Constituents and Biological Activities of Ficus tikoua Bureau

Ficus tikoua Bureau (F. tikoua Bur.) is a perennial woody vine in the Moraceae family that has been used as a traditional folk medicine for centuries to treat many diseases such as chronic

The Antioxidant Activity of Prenylflavonoids

TLDR
Current knowledge on the natural occurrence and structural characteristics of both natural and synthetic derivatives was compiled and an exhaustive survey on the methods used to evaluate the antioxidant potential of these prenylflavonoids was presented.

Characterization of α-glucosidase inhibitory activity of Tetracera scandens leaves by Fourier transform infrared spectroscopy-based metabolomics

Tetracera scandens is a medicinal shrub that belongs to Dilleniaceae. The leaves of the plant have been traditionally used in the treatment of diabetes mellitus in Malaysia. The conventional quality

Synthesis Of Alkoxy-Isoflavones As Potential α-Glucosidase Inhibitors

TLDR
The aromatic moieties of the series of compounds 3 and 4 enhance the inhibitory activity by hydrophobic effects according to docking calculations, suggesting that the attachment of a 4’-chloroacetophenone moiety to the 7-hydroxyl group of 2a-c is an efficient way to increase the inhibition of a-glucosidase.

Flavonoids Isolated from the genus Ficus and Their Biological Activities

TLDR
Flavonoids isolated from the genus Ficus are summarized and their pharmacological effects including anti-bacterial, anti-inflammatory, antitumor, antioxidant, antiviral, protective activities on the cardiovascular system and other activities are summarized.

Flavonoids as alpha-glucosidase inhibitors: mechanistic approaches merged with enzyme kinetics and molecular modelling

Diabetes mellitus is a major, global public health problem. α-Glucosidase inhibitors are one of the most widely used classes of oral antidiabetics. In addition to other pharmaceutical benefits,

A Pharmacological Overview of Alpinumisoflavone, a Natural Prenylated Isoflavonoid

Over the last decade, several studies demonstrated that prenylation of flavonoids enhances various biological activities as compared to the respective nonprenylated compounds. In line with this, the

References

SHOWING 1-10 OF 30 REFERENCES

Isoflavonoids from Ficus benjamina and their inhibitory activity on BACE1.

TLDR
The structures of the eight new compounds were elucidated on the basis of extensive NMR experiments and mass spectrometric measurements and the inhibitory activity of the compounds on the proteolytic cleavage of amyloid precursor protein by the aspartic protease BACE1 was evaluated.

A New Benzofuran Glucoside from Ficus Tikoua Bur

TLDR
From the water-soluble portion of the methanol extract of stems of Ficus tikoua Bur, a new benzofuran glucoside was isolated, named 6-carboxyethyl-5-hydroxybenzofuran 5-O-β-d-glucopyranoside, together with one known benz ofuran glucOSide, which exhibited moderate antioxidant activities.

Chemical Constituents of Rhizomes of Ficus tikoua

The constituents of 90% methanol extract in rhizomes of Ficus tikoua were isolated and purified by repeated chromatography.On the basis of spectral methods,chemical analysis,and reference to the

A new luteolin triglycoside from Ficus ischnopoda leaves

TLDR
A new triglycoside flavone was isolated from the leaves of Ficus ischnopoda, together with five known flavonoids (2–6) and seven known lignans (7–13) and their structures were elucidated on the basis of extensive spectroscopic analysis and comparison with literature data.

Isolation and Identification of α-Glucosidase Inhibitors from Tochu-cha (Eucommia Ulmoides)

TLDR
alpha-Glucosidase inhibitory activity was found in aqueous methanol extracts of tochu-cha, dried leaves of Eucommia ulmoides (Eucommiaceae) and quercetin was considered to contribute mostly to the activity of the tochu leaves.

Monoamine oxidase inhibitory constituents from the fruits ofCudrania tricuspidata

TLDR
A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO) and the kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A competitively inhibited MAO-B.

New Antifungal Pyranoisoflavone from Ficus tikoua Bur.

TLDR
The stem of Ficus tikoua Bur was investigated and one new antifungal pyranoisoflavone was isolated from ethyl acetate extract by bioassay-guided fractionation, determined by spectroscopic analysis, such as NMR, IR, UV and HRMS, as well as ESI-MSn analyses.

Isoflavones from Ficus nymphaefolia

TLDR
A new isoflavone was isolated from the stem bark of Ficus nymphaefolia Mill and their structures were established by spectral analysis including 1D and 2D NMR experiments.

Two new phenolic compounds from Ficus rumphii and their antiproliferative activity

TLDR
The results revealed that compound 4 has better prospectus to act as cancer chemotherapeutic candidate which warrants further in vivo anticancer investigations.

New Alkaloids and α‐Glucosidase Inhibitory Flavonoids from Ficus hispida

TLDR
Two new pyrrolidine alkaloids, ficushispimines A and B, and a new ω‐(dimethylamino)caprophenone alkaloid,ficushisimine C, together with the known alkaloidal 5 and 11 known isoprenylated flavonoids 6 – 16, were isolated from the twigs of Ficus hispida by spectroscopic methods.