Antioxidant and acetylcholinesterase response to repeated malathion exposure in rat cerebral cortex and hippocampus.

@article{Trevisan2008AntioxidantAA,
  title={Antioxidant and acetylcholinesterase response to repeated malathion exposure in rat cerebral cortex and hippocampus.},
  author={Rafael Ortiz Trevisan and Marcela Uliano-Silva and Pablo Pandolfo and Jeferson Lu{\'i}s Franco and Patricia S Brocardo and Adair Roberto Soares dos Santos and Marcelo Farina and Ana L{\'u}cia S Rodrigues and Reinaldo Naoto Takahashi and Alcir Luiz Dafre},
  journal={Basic & clinical pharmacology & toxicology},
  year={2008},
  volume={102 4},
  pages={365-9}
}
The wide use of the organophosphate insecticide malathion is accompanied by the risk of human exposure, especially in developing countries, which underlines the need of basic studies in this area. Some reports have shown that low doses of malathion, in a repeated treatment regimen, are unable to reduce acetylcholinesterase (AChE) activity in the rat brain, in contrast to the inhibitory effect in acute treatment. In order to investigate if AChE activity is affected by repeated low-level… CONTINUE READING