Antioxidant alpha-lipoic acid and protein turnover in insulin-resistant rat muscle.

@article{Weinstein2001AntioxidantAA,
  title={Antioxidant alpha-lipoic acid and protein turnover in insulin-resistant rat muscle.},
  author={Randi B. Weinstein and Hans Juergen Tritschler and Erik John. Henriksen},
  journal={Free radical biology & medicine},
  year={2001},
  volume={30 4},
  pages={
          383-8
        }
}
We have shown previously that the antioxidant alpha-lipoic acid (ALA) can stimulate glucose transport and can enhance the stimulation of this process by insulin in skeletal muscle from insulin-resistant obese Zucker rats. As insulin can also acutely activate general protein synthesis and inhibit net protein degradation in skeletal muscle, we hypothesized that ALA could directly affect protein turnover and also increase the effect of insulin on protein turnover in isolated skeletal muscle from… CONTINUE READING
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