Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress

@article{Mantovani2003AntioxidantAA,
  title={Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress},
  author={Giovanni Mantovani and Antonio Macci{\`o} and Clelia Madeddu and Loredana Mura and Giulia Gramignano and Maria Rita Lusso and E. Rabino Massa and Miria Mocci and Roberto Serpe},
  journal={Journal of Molecular Medicine},
  year={2003},
  volume={81},
  pages={664-673}
}
This study assessed in a wide population of advanced cancer patients the biological parameters relevant to cancer cachexia, such as serum levels of proinflammatory cytokines (IL-1β, IL-6, TNFα), IL-2, acute-phase proteins (C-reactive protein and fibrinogen), leptin, and relevant to oxidative stress (OS), such as ROS, body antioxidant enzymes GPx and SOD. We also studied the ability of effective antioxidant agents α-lipoic acid (ALA), N-acetyl cysteine (NAC), and amifostine (AMI) added into… CONTINUE READING

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