Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling.

@article{McClung2007AntioxidantAA,
  title={Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling.},
  author={Joseph M. McClung and Andreas N. Kavazis and Melissa A. Whidden and Keith C Deruisseau and Darin J. Falk and David S. Criswell and Scott K. Powers},
  journal={The Journal of physiology},
  year={2007},
  volume={585 Pt 1},
  pages={203-15}
}
Oxidative stress promotes controlled mechanical ventilation (MV)-induced diaphragmatic atrophy. Nonetheless, the signalling pathways responsible for oxidative stress-induced muscle atrophy remain unknown. We tested the hypothesis that oxidative stress down-regulates insulin-like growth factor-1-phosphotidylinositol 3-kinase-protein kinase B serine threonine kinase (IGF-1-PI3K-Akt) signalling and activates the forkhead box O (FoxO) class of transcription factors in diaphragm fibres during MV… CONTINUE READING

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