Antioxidant activity of simvastatin prevents ifosfamide-induced nephrotoxicity.

  title={Antioxidant activity of simvastatin prevents ifosfamide-induced nephrotoxicity.},
  author={Nizar Mahmoud Mhaidat and Reem Mustafa Ali and Ali Muhammad Shotar and Almuthanna Khalaf Alkaraki},
  journal={Pakistan journal of pharmaceutical sciences},
  volume={29 2},
Ifosfamide is an anticancer agent used largely in treatment of solid tumors. The mainstay dose-limiting toxicity of ifosfamide is nephrotoxicity. This is largely believde to be a result of ifosfamide-induced oxidative stress. In this study, we investigated the antioxidant activity of simvastatin and the possible protective role of simvastatin against… CONTINUE READING