Antioxidant activity of melatonin and a pinoline derivative on linoleate model system.

@article{Mekhloufi2005AntioxidantAO,
  title={Antioxidant activity of melatonin and a pinoline derivative on linoleate model system.},
  author={Jamila Mekhloufi and Dominique Bonnefont-Rousselot and Saı̈d Yous and Daniel Lesieur and Martine Couturier and Patrice Th{\'e}rond and Alain Legrand and Daniel Jore and Monique Gard{\'e}s-Albert},
  journal={Journal of pineal research},
  year={2005},
  volume={39 1},
  pages={
          27-33
        }
}
This study aimed at investigating the in vitro protective effects of GWC22, a novel pinoline derivative [6-ethyl-1-(3-methoxyphenyl)-2-propyl-1,2,3,4-tetrahydro-beta-carboline] chlorhydrate, against radiation-induced oxidation of linoleate initiated by hydroxyl radicals ((*)OH). Using linoleate micelles (10(-2) m) as lipid model, two indexes of peroxidation have been measured, i.e. conjugated dienes and hydroperoxides. Similar determinations were performed with melatonin in order to compare the… CONTINUE READING
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