Antioxidant activity of ebselen and related selenoorganic compounds in microsomal lipid peroxidation.

@article{Narayanaswami1990AntioxidantAO,
  title={Antioxidant activity of ebselen and related selenoorganic compounds in microsomal lipid peroxidation.},
  author={Vasanthy Narayanaswami and Helmut Sies},
  journal={Free radical research communications},
  year={1990},
  volume={10 4-5},
  pages={237-44}
}
Ebselen, 2-phenyl-1,2-benzisoselenazol-3(2H)one, and its derivatives were compared for their ability to protect microsomal membranes against iron/ADP/ascorbate-induced lipid peroxidation, measured as low-level chemiluminescence and accumulation of thiobarbituric acid-reactive substances (TBARS). The concentrations of the compounds required to double the lag… CONTINUE READING