Antioxidant activity of diethyldithiocarbamate.

  title={Antioxidant activity of diethyldithiocarbamate.},
  author={Jiankang Liu and Mark K. Shigenaga and Liang-Jun Yan and Ave Mori and Bruce N. Ames},
  journal={Free radical research},
  volume={24 6},
Diethyldithiocarbamate (DDC), a potent copper chelating agent, has long been used for the treatment of oxygen toxicity to the central nervous system, as an immunomodulator to treat cancer, and in HIV-infected patients. We evaluated the antioxidant properties of DDC, including its scavenging of reactive oxygen species, its reducing properties, its iron-chelating properties, and its protective effects on oxidant-induced damage to brain tissue, protein, human LDL, and DNA. It is found that DDC is… CONTINUE READING