Antioxidant activity is required for the protective effects of cyclophilin A against oxidative stress.

@article{Kim2015AntioxidantAI,
  title={Antioxidant activity is required for the protective effects of cyclophilin A against oxidative stress.},
  author={Kiyoon Kim and In Kyung Oh and Kyung-Sik Yoon and Joohun Ha and Insug Kang and Wonchae Choe},
  journal={Molecular medicine reports},
  year={2015},
  volume={12 1},
  pages={
          712-8
        }
}
Cyclophilin (Cyp) belongs to a group of proteins that have peptidyl-prolyl cis-trans isomerase (PPIase) activity. CypA is the major cellular target for the immunosuppressive drug cyclosporin A and mediates its actions. Previous studies have demonstrated that CypA has diverse cellular functions and have suggested that CypA may function as an antioxidant. The present study investigated the antioxidant activity of CypA and its association with PPIase activity. The purified CypA/wild-type (WT) and… 

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References

SHOWING 1-10 OF 25 REFERENCES
Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress
TLDR
It is demonstrated that ER stress activates the expression of the ER-localized cyclophilin B (CypB) gene through a novel ER stress response element, and CypB performs a crucial function in protecting cells against ER stress via its PPIase activity.
Cyclophilin A is a secreted growth factor induced by oxidative stress.
TLDR
These findings are the first to identify Cy PA as a secreted redox-sensitive mediator, establish CyPA as a VSMC growth factor, and suggest an important role for CyPA and enzymes with peptidyl-prolyl isomerase activity in the pathogenesis of vascular diseases.
Overexpressed cyclophilin A in cancer cells renders resistance to hypoxia- and cisplatin-induced cell death.
TLDR
It is shown that induction of CypA is associated with Hypoxia in a variety of cells, including DU145 human prostate cancer cell line, and analysis of the CypA promoter clearly showed that CypA up-regulation is mediated by hypoxia-inducible factor-1alpha transcription factor.
Cyclophilins and their possible role in the stress response
TLDR
Current evidence of functional involvement of cyclophilins in various intracellular pathways is reviewed along with the indications that cyclophILin D (Cyp D) represents a crucial part of the mitochondrial permeability transition pore, which is detrimental in apoptotic and necrotic cell death.
The cyclophilins
TLDR
Cyclophilin A is the major cellular target for, and thus mediates the actions of, the immunosuppressive drug cyclosporin A, and form of this complex prevents calcineurin from regulating cytokine gene transcription.
Peptidyl prolyl cis-trans isomerase activity of cyclophilin A in functional homo-oligomeric receptor expression.
  • S. HelekarJ. Patrick
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
TLDR
It is demonstrated that the mechanism of cyclophilin action during functional homo-oligomeric receptor expression in Xenopus oocytes is distinct from the calcineurin-dependent immunosuppressive mechanism by showing that a nonimmunosuppression analog of cyclosporin A (CsA), SDZ 211-811, reduces functional receptor expression to the same extent as CsA.
Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins.
TLDR
A complementary DNA for human cyclophilin C (Cyp-C) was isolated from a human kidney cDNA library and northern blot experiments revealed that Cyp-C is less abundant than Cyp-A, arguing against a previously postulated specific role for Cyp- C in the nephrotoxic effects of CsA in humans.
Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions
TLDR
Exposure to cisplatin induces a mitochondrial-dependent ROS response that significantly enhances the cytotoxic effect caused by nDNA damage and may lead to the design of novel therapeutic strategies to improve anticancer drug efficacy.
Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons.
TLDR
The notion that Ape 1 is a potential translational target such that protecting Ape1 levels and particularly its DNA repair function could reduce peripheral neuropathy in patients undergoing cisplatin treatment is strongly supported.
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