Antioxidant activity is required for the protective effects of cyclophilin A against oxidative stress.

  title={Antioxidant activity is required for the protective effects of cyclophilin A against oxidative stress.},
  author={Kiyoon Kim and In Kyung Oh and Kyung-Sik Yoon and Joohun Ha and Insug Kang and Wonchae Choe},
  journal={Molecular medicine reports},
  volume={12 1},
Cyclophilin (Cyp) belongs to a group of proteins that have peptidyl-prolyl cis-trans isomerase (PPIase) activity. CypA is the major cellular target for the immunosuppressive drug cyclosporin A and mediates its actions. Previous studies have demonstrated that CypA has diverse cellular functions and have suggested that CypA may function as an antioxidant. The present study investigated the antioxidant activity of CypA and its association with PPIase activity. The purified CypA/wild-type (WT) and… 

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The cyclophilins
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Peptidyl prolyl cis-trans isomerase activity of cyclophilin A in functional homo-oligomeric receptor expression.
  • S. HelekarJ. Patrick
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
It is demonstrated that the mechanism of cyclophilin action during functional homo-oligomeric receptor expression in Xenopus oocytes is distinct from the calcineurin-dependent immunosuppressive mechanism by showing that a nonimmunosuppression analog of cyclosporin A (CsA), SDZ 211-811, reduces functional receptor expression to the same extent as CsA.
Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins.
A complementary DNA for human cyclophilin C (Cyp-C) was isolated from a human kidney cDNA library and northern blot experiments revealed that Cyp-C is less abundant than Cyp-A, arguing against a previously postulated specific role for Cyp- C in the nephrotoxic effects of CsA in humans.
Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions
Exposure to cisplatin induces a mitochondrial-dependent ROS response that significantly enhances the cytotoxic effect caused by nDNA damage and may lead to the design of novel therapeutic strategies to improve anticancer drug efficacy.
Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons.
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