Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen.

@article{Jabrek2013AntioxidantAB,
  title={Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen.},
  author={Martin Jabůrek and Jan Jezek and Jaroslav Zelenka and Petr Jezek},
  journal={The international journal of biochemistry & cell biology},
  year={2013},
  volume={45 4},
  pages={
          816-25
        }
}
Mitochondrial uncoupling protein-2 (UCP2) has been suggested to participate in the attenuation of the reactive oxygen species production, but the mechanism of action and the physiological significance of UCP2 activity remain controversial. Here we tested the hypothesis that UCP2 provides feedback downregulation of oxidative stress in vivo via synergy with an H2O2-activated mitochondrial calcium-independent phospholipase A2 (mt-iPLA2). Tert-butylhydroperoxide or H2O2 induced free fatty acid… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 67 REFERENCES

Mitochondrial Complex I superoxide production is attenuated by uncoupling.

  • The international journal of biochemistry & cell biology
  • 2008
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

bioenergetic phenotype

DJ Mancuso, HF Sims, +3 authors CM Jenkins
  • Journal of Biological Chemistry
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

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