Antioxidant Protective Mechanisms against Reactive Oxygen Species (ROS) Generated by Mitochondrial P450 Systems in Steroidogenic Cells

  title={Antioxidant Protective Mechanisms against Reactive Oxygen Species (ROS) Generated by Mitochondrial P450 Systems in Steroidogenic Cells},
  author={Israel Hanukoglu},
  journal={Drug Metabolism Reviews},
  pages={171 - 196}
  • Israel Hanukoglu
  • Published 2006
  • Medicine, Chemistry
  • Drug Metabolism Reviews
  • Mitochondrial P450 type enzymes catalyze central steps in steroid biosynthesis, including cholesterol conversion to pregnenolone, 11β and 18 hydroxylation in glucocorticoid and mineralocorticoid synthesis, C-27 hydroxylation of bile acids, and 1α and 24 hydroxylation of 25-OH-vitamin D. These monooxygenase reactions depend on electron transfer from NADPH via FAD adrenodoxin reductase and 2Fe-2S adrenodoxin. These systems can function as a futile NADPH oxidase, oxidizing NADPH in absence of… CONTINUE READING
    194 Citations
    From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D.
    • 21
    • PDF
    Manganese Superoxide Dismutase: Guardian of the Powerhouse
    • 144
    • PDF
    How mitochondria produce reactive oxygen species
    • M. Murphy
    • Medicine, Biology
    • The Biochemical journal
    • 2009
    • 4,658
    • PDF
    Oxidative stress and adrenocortical insufficiency
    • 31
    • Highly Influenced
    • PDF
    Regulation of reactive oxygen species generation in cell signaling
    • 350
    • Highly Influenced
    • PDF
    Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway.
    • 47
    • PDF


    Routes and regulation of NADPH production in steroidogenic mitochondria.
    • 47
    • PDF
    Mitochondrial generation of reactive oxygen species and its role in aerobic life.
    • 401
    • PDF
    Mitochondrial Production of Oxygen Radical Species and the Role of Coenzyme Q as an Antioxidant
    • 130
    Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria
    • 18
    • Highly Influential
    Role of cytochrome P-450 in the stimulation of microsomal production of reactive oxygen species by ferritin.
    • 38
    Minireview: regulation of steroidogenesis by electron transfer.
    • W. Miller
    • Chemistry, Medicine
    • Endocrinology
    • 2005
    • 280
    • PDF
    Sources of reducing equivalents for cytochrome P-450 mitochondrial steroid hydroxylations in rat adrenal cortex cells.
    • 9
    Oxidative Stress and the Ovary
    • 210