Antioxidant Potential and Protection of Pancreatic ?- cells by Calotropis gigantea in Streptozocin Induced Diabetic Rats

  title={Antioxidant Potential and Protection of Pancreatic ?- cells by Calotropis gigantea in Streptozocin Induced Diabetic Rats},
  author={Naveen Kumar Choudhary and Swapnil Sharma and Arvind Kumar Jha and Manvendra Singh Karchuli and Jaya Dwivedi},
  journal={Journal of Complementary and Integrative Medicine},
This study was designed to examine the antioxidant defense by chloroform extract of Calotropis gigantea on streptozotocin-(40mg/kg, intraperitonial, single-injection) induced diabetes in wistar albino rats. The extract significantly (P < .05) decreased the pancreatic thiobarbituric acid-reactive substances (TBARS) levels and significantly (P < .05) increased the superoxide dismutase, catalase, and glutathione levels as compared to above levels in pancreatic tissue of pathogenic diabetic rats… Expand
Anti-Diabetic Effects of Amygdalus Lycioides Spach in Streptozocin-Induced Diabetic Rats
It seems that Amygdalus lycioides may act as a potential drug to treat diabetes and its complications, but more investigations should be done to more clarify these results. Expand
Herbal Medicines Targeting the Improved β-Cell Functions and β-Cell Regeneration for the Management of Diabetes Mellitus
Herbal medicines with the potential for improvement of β-cell functions and regeneration as scientifically proven by in vivo/in vitro investigations and their structure-activity relationship (SAR), and toxicities are summarized. Expand
Chemometric Profile of Calotropis gigantea and its Antioxidant Activity through Bioactive Compounds from Latex, Leaves and Flower Extracts
In present study, antioxidant effect was compared among latex, leaf and flower extract of Calotropis gigantea and is first report on comparing the chemometric profiling of various parts of C.Expand
The rapid increase in incidence of Diabetes mellitus is becoming a serious threat to the people all over the world. It is considered as one of the most common non-communicable diseases globally. TillExpand
An ethnobotanical survey of antidiabetic medicinal plants used by the Bodo tribe of Kokrajhar district, Assam
Diabetes mellitus (DM) belongs to the group of diseases causing major health problems in India and world at large. Natural products including medicinal plants are known to treat various diseasesExpand


Free Radical Scavenging Activity of Calotropis gigantea on Streptozotocin-Induced Diabetic Rats
It was observed that the effect of chloroform extracts of Calotropis gigantea on alkaline phosphatase, cholesterol, superoxide dismutase, serum glutamic pyruvic transaminase, alkaline phosphate, cholesterol and triglyceride levels are comparable to that of those produced by the positive control. Expand
Antioxidant effect of Boerhavia diffusa L. in tissues of alloxan induced diabetic rats.
The results suggest that BLEt has remarkable antidiabetic activity and can improve antioxidant status in alloxan induced diabetic rats. Expand
Effect of aminoguanidine on lipid peroxidation in streptozotocin-induced diabetic rats.
Results suggest that AMGN may have an additional beneficial effect as an antioxidant against lipid peroxidation in a prevention trial for diabetic vascular complications. Expand
Effect of Syzigium cumini in Plasma Antioxidants on Alloxan-Induced Diabetes in Rats
We undertook the present study to evaluate the antioxidant activity of an aqueous extract of the seeds of Syzigium cumini, an indigenous plant present in different parts of India, South-East Asia andExpand
Restoration on tissue antioxidants by fenugreek seeds (Trigonella Foenum Graecum) in alloxan-diabetic rats.
It is suggested that the soluble portion of the seeds could be responsible for the antioxidant property, and supplementation resulted in increased antioxidant status with reduction in peroxidation. Expand
Superoxide dismutase is a prophylactic against alloxan diabetes
It is reported that injections of superoxide dismutase, an enzyme removing superoxide anion radicals, act prophylactically against alloxan-induced diabetes. Expand
Antihyperglycaemic And Anti‐Oxidant Properties Of Andrographis Paniculata In Normal And Diabetic Rats
  • Xiang‐Fan Zhang, B. Tan
  • Chemistry, Medicine
  • Clinical and experimental pharmacology & physiology
  • 2000
The ethanolic extract of the aerial parts of Andrographis paniculata is investigated for antihyperglycaemic and anti‐ oxidant effects in normal and streptozotocin‐induced type I diabetic rats. Expand
Effect of curcumin on the advanced glycation and cross-linking of collagen in diabetic rats.
The significance of free radicals in the accumulation of AGEs and cross-linking of collagen in diabetes confirms the significance of curcumin administration for the prevention of A GE-induced complications of diabetes mellitus. Expand
Evaluation of antipyretic activity of Calotropis gigantea (Asclepiadaceae) in experimental animals
It can be concluded that the extract of C. gigantea has potential antipyretic activity against both yeast‐induced and TAB vaccine‐induced fever, indicating the possibility of developing C. gigsantea as a cheaper and potent antipYretic agent. Expand
Studies on anti-diarrhoeal activity of Calotropis gigantea R.Br. in experimental animals.
  • H. Chitme, M. Chandra, S. Kaushik
  • Biology, Medicine
  • Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2004
The remarkable anti-diarrheal effect of C.gigantea extract against castor oil-induced diarrhea model attests to its utility in a wide range of diarrheal states. Expand