Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice.

@article{Reliene2006AntioxidantNC,
  title={Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice.},
  author={Ramune Reliene and Robert H. Schiestl},
  journal={DNA repair},
  year={2006},
  volume={5 7},
  pages={
          852-9
        }
}
Hereditary human disorder ataxia telangiectasia (AT) is characterized by an extremely high incidence of lymphoid malignancies, neuromotor dysfunction, immunodeficiency and radiosensitivity. Cells from AT patients show genetic instability and a continuous state of oxidative stress. We examined the effect of long-term dietary supplementation with the thiol-containing antioxidant, N-acetyl-L-cysteine (NAC), on survival and cancer formation in Atm (AT-mutated) deficient mice, used as an animal… CONTINUE READING
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