Antioxidant Inhibits HMGB1 Expression and Reduces Pancreas Injury in Rats with Severe Acute Pancreatitis

@article{Zhang2009AntioxidantIH,
  title={Antioxidant Inhibits HMGB1 Expression and Reduces Pancreas Injury in Rats with Severe Acute Pancreatitis},
  author={Zhong Wei Zhang and Qi Zhang and Meng Tao Zhou and Na Liu and Tong Chen and Ye Zhu and Liang Wu},
  journal={Digestive Diseases and Sciences},
  year={2009},
  volume={55},
  pages={2529-2536}
}
Pathogenesis of severe acute pancreatitis is still unclear, which leads to a lack of proper treatment in severe acute pancreatitis therapeutic strategy. To investigate the effect of treatment with antioxidant pyrrolidine dithiocarbamate on pancreas injury in rats with severe acute pancreatitis and its possible mechanism. A total of 144 male Sprague–Dawley rats were randomly allocated into a sham operation group (n = 48), a severe acute pancreatitis group (n = 48), and a pyrrolidine… CONTINUE READING
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