Antioxidant Improves Smooth Muscle Sarco/Endoplasmic Reticulum Ca2+-ATPase Function and Lowers Tyrosine Nitration in Hypercholesterolemia and Improves Nitric Oxide–Induced Relaxation

@article{Adachi2002AntioxidantIS,
  title={Antioxidant Improves Smooth Muscle Sarco/Endoplasmic Reticulum Ca2+-ATPase Function and Lowers Tyrosine Nitration in Hypercholesterolemia and Improves Nitric Oxide–Induced Relaxation},
  author={T. Adachi and R. Matsui and Shanqin Xu and M. Kirber and H. Lazar and V. Sharov and C. Sch{\"o}neich and R. Cohen},
  journal={Circulation Research: Journal of the American Heart Association},
  year={2002},
  volume={90},
  pages={1114-1121}
}
  • T. Adachi, R. Matsui, +5 authors R. Cohen
  • Published 2002
  • Chemistry, Medicine
  • Circulation Research: Journal of the American Heart Association
Antioxidants improve endothelial function in hypercholesterolemia (HC); however, whether this includes improvement of the vascular smooth muscle response to NO is unknown. NO relaxes arteries, in part, by stimulating Ca2+ uptake via sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in aortic smooth muscle, and HC impairs SERCA function and the response to NO. HC induces oxidative stress, which could impair SERCA function. To study the effect of antioxidants, which are known to improve endothelium… Expand
Modulation of vascular sarco/endoplasmic reticulum calcium ATPase in cardiovascular pathophysiology.
  • T. Adachi
  • Chemistry, Medicine
  • Advances in pharmacology
  • 2010
Effects of peroxynitrite on sarcoplasmic reticulum Ca2+ pump in pig coronary artery smooth muscle.
Cysteine-674 oxidation and degradation of sarcoplasmic reticulum Ca(2+) ATPase in diabetic pig aorta.
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