Antioxidant Effects of N‐Acetylserotonin

@article{Oxenkrug2005AntioxidantEO,
  title={Antioxidant Effects of N‐Acetylserotonin},
  author={Gregory F Oxenkrug},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1053}
}
  • G. Oxenkrug
  • Published 1 August 2005
  • Biology
  • Annals of the New York Academy of Sciences
Abstract: This paper will review our recent data relevant to the antioxidant effects of N‐acetylserotonin (NAS), the immediate precursor of melatonin, the pineal gland indole. Mechanisms of the antioxidant effects of NAS might involve interaction with melatonin type 3 receptors and nonreceptor mechanisms such as stimulation of glutathione peroxidase, an antioxidant enzyme; inhibition of lipid peroxidation; suppression of phospholipase A2 activation; attenuation of tumor necrosis factor… 

Antioxidant Activities of Synthetic Indole Derivatives and Possible Activity Mechanisms

TLDR
Another perspective on antioxidant activities of synthetic melatonin analogues is given, given that Epidemiological studies have been strongly suggesting that antioxidants can decrease the rate of many diseases.

The influence of ageing on the extrapineal melatonin synthetic pathway

Effect of Methyl Derivatives of Dopamine on Tumor Necrosis Factor α and Lipid Peroxidation

TLDR
The results indicated that the inhibitory effect of NAS, NAD, NMD, or 4‐O‐MD on LPS‐induced TNF‐α production and FeCl2‐stimulated lipid peroxidation is robust and dose dependent.

Quinone reductase 2 and antidepressant effect of melatonin derivatives

TLDR
The results suggest that the modulation of QR2/MT3 might contribute to mechanism(s) of antidepressant effect of NAS and melatonin, and new antidepressants might be searched among the agonists of QR3.

Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

TLDR
Melatonin's family is rather exceptional, offering versatile and collective antioxidant protection against OS, and it certainly seems that melatonin is one of nature's defenses against oxidative damage.

Serotonin and its metabolites reduce oxidative stress in murine RAW264.7 macrophages and prevent inflammation

TLDR
Serotonin plays a key role in modulation of inflammation and the regulatory functions of immune cells, while also protecting cells against oxidative stress, and antioxidant capacity of tested compounds is a major advantage in the early stages of inflammation.

Effect of N‐Acetylserotonin on TLR‐4 and MyD88 Expression during Intestinal Ischemia‐Reperfusion in a Rat Model

  • I. SukhotnikY. B. Shahar A. Bitterman
  • Medicine, Biology
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
  • 2019
TLDR
Treatment with NAS is associated with downregulation of TLR‐4, MyD88, and TRAF6 expression along with a concomitant decrease in intestinal mucosal injury caused by intestinal IR in a rat.

Pharmacology of Melatonin and Its Receptors

TLDR
This chapter discusses in detail the various aspects of melatonin with its key role in the body and how this versatile hormone and its receptors work in a synchronized way to alter the pathophysiological processes of the body according to the biological clock and circadian rhythm.

Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders

This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)–kynurenine (KYN) and

N-acetylserotonin: circadian activation of the BDNF receptor and neuroprotection in the retina and brain.

TLDR
It is shown that TrkB activation in the retina and hippocampus is circadian in C3H/f(+/+) mice, which synthesize NAS, but not in C57BL/6 mice, who have a mutation in the gene encoding the enzyme that converts serotonin to NAS.

References

SHOWING 1-10 OF 79 REFERENCES

Antioxidant and Antiaging Activity of N‐Acetylserotonin and Melatonin in the in Vivo Models

TLDR
This study demonstrates, for the first time, the antiaging effect of N‐acetylserotonin, a melatonin precursor and metabolite, in animals with impaired capacity to convert pineal NAS into melatonin.

Relative efficacies of indole antioxidants in reducing autoxidation and iron‐induced lipid peroxidation in hamster testes

TLDR
Melatonin and related indoles at pharmacological concentrations protect against both the autoxidation of lipids as well as induced peroxidationof lipids in testes.

Inhibition of lipid peroxidation by N-acetylserotonin and its role in retinal physiology.

TLDR
N-Acetylserotonin reduces the rate of ABAP-initiated lipid peroxidation in a concentration-dependent manner, and it is suggested that NAS acts as a physiological antioxidant in retinal photoreceptor cells.

Effect of melatonin and metabolites on copper-mediated oxidation of flow density lipoprotein.

TLDR
The present results indicate that the pineal hormone melatonin appears to have little antiatherogenic property as regards the oxidation of LDL, however, its main breakdown product 6-hydroxymelatonin inhibits LDL-oxidation comparable to vitamin E.

N‐acetyl‐serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF‐κB

TLDR
Normelatonin's and melatonin's neuroprotective activity in SK‐N‐MC neuroblastoma cells may be mediated by the suppression of NF‐κB activation, and normelatonin was more potent in the suppressing of the activation of NF-κB by H2O2 in SK-N-MC cells compared to melatonin, no apparent differences in the extent of suppression could be detected in primary neurons.

The neuroprotective activities of melatonin against the Alzheimer β‐protein are not mediated by melatonin membrane receptors

TLDR
The neuroprotective properties ofmelatonin against Aβ‐mediated toxicity does not require binding of melatonin to a membrane receptor and is likely the result of the antioxidant and antiamyloidogenic features of the agent.

Protective effect of indoleamines on in vitro ascorbate‐Fe2+dependent lipid peroxidation of rod outer segment membranes of bovine retina

TLDR
N‐acetylserotonin shows a protective effect about 20 times higher than that of melatonin, andRod outer segment membranes are highly vulnerable to autooxidation because of their high content of long chain polyunsaturated fatty acids (PUFAs).

N‐Acetylserotonin, Melatonin and Their Derivatives Improve Cognition and Protect against β‐Amyloid‐Induced Neurotoxicity

TLDR
The results suggest that neuroprotecting properties of these compounds might mediate their cognition‐enhancing effects and warrant the further search for the novel types of safe neuroprotectors among the synthetic NAS/melatonin derivatives.
...